Université de Toulouse, 135 Avenue de Rangueil, Toulouse, France.
Bioinformatics. 2012 May 1;28(9):1294-6. doi: 10.1093/bioinformatics/bts127. Epub 2012 Mar 13.
Mass spectrometry (MS) is widely used for isotopic labeling studies of metabolism and other biological processes. Quantitative applications-e.g. metabolic flux analysis-require tools to correct the raw MS data for the contribution of all naturally abundant isotopes. IsoCor is a software that allows such correction to be applied to any chemical species. Hence it can be used to exploit any isotopic tracer, from well-known ((13)C, (15)N, (18)O, etc) to unusual ((57)Fe, (77)Se, etc) isotopes. It also provides new features-e.g. correction for the isotopic purity of the tracer-to improve the accuracy of quantitative isotopic studies, and implements an efficient algorithm to process large datasets. Its user-friendly interface makes isotope labeling experiments more accessible to a wider biological community.
IsoCor is distributed under OpenSource license at http://metasys.insa-toulouse.fr/software/isocor/
质谱（MS）广泛用于代谢和其他生物过程的同位素标记研究。定量应用，例如代谢通量分析，需要工具来校正原始 MS 数据中所有天然丰度同位素的贡献。IsoCor 是一种软件，允许对任何化学物质进行此类校正。因此，它可用于利用任何同位素示踪剂，从众所周知的（13C、15N、18O 等）到不寻常的（57Fe、77Se 等）同位素。它还提供了新的功能，例如示踪剂同位素纯度的校正，以提高定量同位素研究的准确性，并实现了一种有效的算法来处理大型数据集。其用户友好的界面使更多的生物界更容易进行同位素标记实验。
IsoCor 根据开源许可证发布，可在 http://metasys.insa-toulouse.fr/software/isocor/ 获得。
