Kleijnen J, Ter Riet G, Knipschild P
Department of Epidemiology/Health Care Research, University of Limburg, Maastricht, The Netherlands.
Br J Obstet Gynaecol. 1990 Sep;97(9):847-52. doi: 10.1111/j.1471-0528.1990.tb02582.x.
A search of the literature yielded 12 controlled trials on vitamin B6 in the treatment of the premenstrual syndrome. These are discussed with emphasis on methodological aspects. A major drawback of the trials is the limited number of patients included. The existing evidence of positive effects of vitamin B6 is weak, and some well-designed trials with positive results would be needed to change this view.