Schatz G
Klin Wochenschr. 1979 Jun 15;57(12):641-6. doi: 10.1007/BF01477631.
Biological membranes are essentially asymmetric two-dimensional solutions of proteins in a bimolecular lipid layer. The overall structure and many physical properties of biological membranes can be explained by the fact that membrane proteins and membrane lipids contain hydrophilic as well as hydrophobic domains. Most biological properties of the membrane are determined by the membrane proteins which can catalyze directional processes. With the membrane protein cytochrome oxidase it will be demonstrated how the three-dimensional arrangement of membrane proteins can be studied by chemical, fluorometric, and electron optical methods. However, it is in most cases still impossible to explain the function of a membrane on the basis of its molecular architecture.
生物膜本质上是蛋白质在双分子脂质层中的不对称二维溶液。生物膜的整体结构和许多物理性质可以通过膜蛋白和膜脂既含有亲水结构域又含有疏水结构域这一事实来解释。膜的大多数生物学特性是由能够催化定向过程的膜蛋白所决定的。以膜蛋白细胞色素氧化酶为例，将展示如何通过化学、荧光和电子光学方法来研究膜蛋白的三维排列。然而，在大多数情况下，仍然无法根据膜的分子结构来解释其功能。
