Division of Pediatric Neurology, Duke University Medical Center, Durham, NC 27710, USA.
Epileptic Disord. 2012 Mar;14(1):99-103. doi: 10.1684/epd.2012.0491.
Oxcarbazepine has been reported to precipitate myoclonic, generalised tonic-clonic, absence, and complex partial seizures, and carbamazepine to precipitate absences, myoclonic seizures and spasms. Here, we report a one-year, six-month-old girl with complex partial seizures who developed infantile spasms, developmental regression, and hypsarrhythmia during the two weeks directly following initiation of oxcarbazepine (14 mg/kg/day). All of these resolved within a few days after discontinuation of this medication. Although we cannot rule out that the above association may have been coincidental, or that the improvement may have been due to concurrent therapy, this case raises the possibility that oxcarbazepine, like carbamazepine, may precipitate infantile spasms and West syndrome.
奥卡西平已被报道可诱发肌阵挛、全面强直-阵挛、失神和复杂部分性发作，卡马西平可诱发失神、肌阵挛发作和痉挛。在此，我们报告一例 1 岁 6 个月的女孩，在开始服用奥卡西平（14mg/kg/天）后的两周内出现复杂部分性发作、发育倒退和高度失律，这些症状在停药后几天内得到缓解。虽然我们不能排除上述关联可能是巧合，或者改善可能是由于同时进行的治疗，但这个病例提示奥卡西平可能像卡马西平一样诱发婴儿痉挛症和 West 综合征。
