Berger Nathalie, Dubreucq Bertrand
Institut Jean-Pierre Bourgin, Versailles, France.
Biochim Biophys Acta. 2012 Aug;1819(8):863-8. doi: 10.1016/j.bbagrm.2012.02.022. Epub 2012 Mar 8.
Chromatin-associated proteins (CAP) play a crucial role in the regulation of gene expression and development in higher organisms. They are involved in the control of chromatin structure and dynamics. CAP have been extensively studied over the past years and are classified into two major groups: enzymes that modify histone stability and organization by post-translational modification of histone N-Terminal tails; and proteins that use ATP hydrolysis to modify chromatin structure. All of these proteins show a relatively high degree of sequence conservation across the animal and plant kingdoms. The essential Drosophila melanogaster GAGA factor (dGAF) interacts with these two types of CAP to regulate homeobox genes and thus contributes to a wide range of developmental events. Surprisingly, however, it is not conserved in plants. In this review, following an overview of fly GAF functions, we discuss the role of plant BBR/BPC proteins. These appear to functionally converge with dGAF despite a completely divergent amino acid sequence. Some suggestions are given for further investigation into the function of BPC proteins in plants.
染色质相关蛋白（CAP）在高等生物的基因表达调控和发育过程中起着至关重要的作用。它们参与染色质结构和动态变化的控制。在过去几年中，CAP已得到广泛研究，并被分为两大类：通过对组蛋白N端尾部进行翻译后修饰来改变组蛋白稳定性和组织的酶；以及利用ATP水解来改变染色质结构的蛋白质。所有这些蛋白质在动植物界都表现出相对较高程度的序列保守性。至关重要的果蝇GAGA因子（dGAF）与这两类CAP相互作用，以调控同源异型框基因，从而参与广泛的发育事件。然而，令人惊讶的是，它在植物中并不保守。在本综述中，在概述果蝇GAF功能之后，我们讨论了植物BBR/BPC蛋白的作用。尽管氨基酸序列完全不同，但这些蛋白在功能上似乎与dGAF趋同。文中还给出了一些关于进一步研究植物中BPC蛋白功能的建议。
