Kozlovskaya Veronika, Baggett Jennifer, Godin Biana, Liu Xuewu, Kharlampieva Eugenia
Department of Chemistry, University of Alabama at Birmingham, Birmingham, Alabama, 35294, USA.
ACS Macro Lett. 2012 Feb 24;2012(1):384-387. doi: 10.1021/mz200118f.
We present a novel type of all-aqueous non-ionic layer-by-layer films of silk fibroin with synthetic macromolecules and a natural polyphenol. We found the multilayer growth and stability to be strongly pH-dependent. Silk assembled with poly(methacrylic) and tannic acids at pH=3.5 disintegrated at pH~5; while silk/poly(N-vinylcaprolactam) interactions were stable at low and high pH values but resulting in thinner films at high pH. The results suggest that the intermolecular interactions are primary driven by hydrogen bonding with a considerable contribution of hydrophobic forces. We also demonstrated that cubical, spherical and platelet capsules with silk-containing walls can be constructed using particulate sacrificial templates. This work sets a foundation for future explorations of natural and synthetic macromolecules assemblies as biomimetic materials with tunable properties.
我们展示了一种新型的由丝素蛋白与合成大分子和天然多酚构成的全水性非离子层层薄膜。我们发现多层膜的生长和稳定性强烈依赖于pH值。在pH = 3.5时，丝素蛋白与聚（甲基丙烯酸）和单宁酸组装而成的多层膜在pH约为5时会解体；而丝素蛋白/聚（N-乙烯基己内酰胺）相互作用在低pH值和高pH值下都很稳定，但在高pH值下会形成更薄的薄膜。结果表明，分子间相互作用主要由氢键驱动，疏水力也有相当大的贡献。我们还证明了可以使用颗粒牺牲模板构建具有含丝壁的立方体、球形和片状胶囊。这项工作为未来探索天然和合成大分子组装体作为具有可调性质的仿生材料奠定了基础。
