Pocock J M, Nicholson R A, Osborne M P
Department of Physiology, Medical School, University of Birmingham, UK.
J Neurocytol. 1990 Aug;19(4):574-83. doi: 10.1007/BF01257245.
The treatment of locusts (Schistocerca gregaria) with colchicine leads to various changes in the ultrastructure of both central and peripheral nerve terminals. These changes include a marked reduction in synaptic vesicle density, which is further enhanced following stimulation. There are also increased numbers of coated pits and membraneous cisternae together with enlarged terminal areas and disruption of mitochondrial ultrastructure. The capacity of isolated central nerve terminals (synaptosomes) to take up the radiolabelled transmitter precursor [3H]-choline is enhanced following in vivo treatment of locusts with colchicine, whilst in vitro treatment leads to a reduction in choline uptake. The results are discussed with regard to the postulated effects of colchicine on axoplasmic transport.
用秋水仙碱处理蝗虫（飞蝗）会导致中枢和外周神经末梢的超微结构发生各种变化。这些变化包括突触小泡密度显著降低，刺激后这种降低会进一步加剧。此外，有被小窝和膜性池的数量增加，同时终末区域扩大，线粒体超微结构遭到破坏。在用秋水仙碱对蝗虫进行体内处理后，分离出的中枢神经末梢（突触体）摄取放射性标记的递质前体[3H] - 胆碱的能力增强，而体外处理则导致胆碱摄取减少。结合秋水仙碱对轴浆运输的假定作用对这些结果进行了讨论。
