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标准经皮肾镜取石术与无管经皮肾镜取石术:一项系统评价

Standard versus tubeless percutaneous nephrolithotomy: a systematic review.

作者信息

Amer Tarik, Ahmed Kamran, Bultitude Matthew, Khan Shahid, Kumar Pardeep, De Rosa Antonella, Khan Mohammed Shamim, Hegarty Nicholas

机构信息

Department of Urology, Guy's Hospital, MRC Centre for Transplantation, King's College London, King's Health Partners, London, UK.

出版信息

Urol Int. 2012;88(4):373-82. doi: 10.1159/000336145. Epub 2012 Mar 19.

Abstract

OBJECTIVE

This article systematically analyses comparative studies to evaluate the efficacy and safety of tubeless percutaneous nephrolithotomy (PCNL) versus standard PCNL.

METHODS

The Medline, EMBASE, PsycINFO, Cochrane and DARE databases were searched from 1997 to February 2011. Comparative studies evaluating outcomes from standard versus tubeless PCNL were included. Primary outcome measures were post-operative pain scoring, analgesic requirements, duration of hospitalisation/convalescence, operation time, major/minor complications and stone-free rates.

RESULTS

Twenty-four studies were included (11 randomised control trials and 13 retrospective or prospective studies). Levels of pain recorded, analgesic requirements, duration of inpatient stay and convalescence time were all significantly reduced in the tubeless PCNL group. Cost was reduced in two studies. Morbidity was not significantly different between the groups. There was no significant difference between groups regarding stone-free status.

DISCUSSION

This systematic review has demonstrated that tubeless PCNL is a viable alternative to tubed PCNL in uncomplicated cases. Benefits are as described above. There is no evidence suggesting that patient safety is compromised by the absence of post-operative nephrostomy. The tubeless method has been reported in challenging cases such as stag-horn stones, horseshoe or ectopic kidneys. Promising outcomes have been demonstrated in elderly patients and when clinical needs demand a supracostal approach. Multi-centre randomised controlled trials are needed to fully establish the effectiveness of the tubeless method.

摘要

目的

本文系统分析比较性研究,以评估无管经皮肾镜取石术(PCNL)与标准PCNL的疗效和安全性。

方法

检索1997年至2011年2月的Medline、EMBASE、PsycINFO、Cochrane和DARE数据库。纳入评估标准PCNL与无管PCNL结果的比较性研究。主要结局指标为术后疼痛评分、镇痛需求、住院/康复时间、手术时间、严重/轻微并发症及结石清除率。

结果

纳入24项研究(11项随机对照试验和13项回顾性或前瞻性研究)。无管PCNL组记录的疼痛程度、镇痛需求、住院时间和康复时间均显著降低。两项研究中成本降低。两组间发病率无显著差异。结石清除状态在组间无显著差异。

讨论

该系统评价表明,在非复杂病例中,无管PCNL是有管PCNL的可行替代方法。益处如上所述。没有证据表明术后未留置肾造瘘管会损害患者安全。无管方法已在鹿角形结石、马蹄肾或异位肾等具有挑战性的病例中报道。在老年患者以及临床需要采用肋上入路时已显示出有前景的结果。需要多中心随机对照试验来充分确立无管方法的有效性。

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