Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Dement Geriatr Cogn Disord. 2012;33(2-3):90-5. doi: 10.1159/000337038. Epub 2012 Mar 16.
AIMS: We examine the dementia assessment with focus on age and gender differences. METHODS: Data from the national quality database, Swedish Dementia Registry (SveDem), including 6,937 dementia patients diagnosed during 2007-2009 at memory clinics were used. We have studied the use of investigations for dementia diagnostics such as cognitive tests, blood and cerebrospinal fluid analyses, electroencephalography, radiological examinations and assessments of functions. Severity of cognitive impairment was assessed with the Mini Mental State Examination (MMSE). RESULTS: There was a significant decrease in the number of total tests used in the elderly group (>75 years) when compared with the middle-aged group (65-75 years) and younger patients (<65 years). The oldest group was examined with 4 of 11 possible tests, the middle-aged group had 5/11 tests performed and the youngest age group 6/11 tests. There was also a significant gender difference in the diagnostic workup, however, mostly attributable to age. The number of tests positively correlated with the level of cognition assessed by the MMSE. CONCLUSION: We show here for the first time the impact of age, gender and MMSE score on the dementia diagnostic workup in a large memory clinic patient population in one country.
目的:我们研究了痴呆症评估,重点关注年龄和性别差异。
方法:使用来自全国质量数据库瑞典痴呆症登记处(SveDem)的数据,包括 2007-2009 年在记忆诊所诊断的 6937 例痴呆症患者。我们研究了用于痴呆症诊断的检查,如认知测试、血液和脑脊液分析、脑电图、影像学检查和功能评估。认知障碍的严重程度采用简易精神状态检查(MMSE)评估。
结果:与中年组(65-75 岁)和年轻患者(<65 岁)相比,老年组(>75 岁)使用的总测试数量显著减少。最年长的组接受了 11 项可能测试中的 4 项,中年组进行了 5/11 项测试,最年轻的年龄组进行了 6/11 项测试。诊断工作中也存在显著的性别差异,但主要归因于年龄。测试数量与 MMSE 评估的认知水平呈正相关。
结论:我们首次在一个国家的大型记忆诊所患者人群中,展示了年龄、性别和 MMSE 评分对痴呆症诊断工作的影响。
Dement Geriatr Cogn Disord. 2012-3-16
Int J Geriatr Psychiatry. 2013-2-26
Int J Geriatr Psychiatry. 1997-6
Ugeskr Laeger. 2006-5-29
Dement Geriatr Cogn Disord. 2012-3-9
Brain Nerve. 2009-8
SSM Popul Health. 2023-12-2
Front Aging Neurosci. 2022-2-7
J Alzheimers Dis. 2017
Alzheimers Res Ther. 2016-11-18