Feldman R G, Niles C A, Kelly-Hayes M, Sax D S, Dixon W J, Thompson D J, Landau E
Neurology. 1979 Jul;29(7):939-44. doi: 10.1212/wnl.29.7.939.
We conducted a double-blind controlled study of individuals exposed to arsenic trioxide in a copper-smelting factory. Subjects fell into three categories of peripheral neuropathy: none, subclinical, and clinical. The subclinical group had no symptoms or signs of numbness or reduced reflexes, but did have reduced nerve conduction velocity and amplitude measurements. Clinical neuropathy groups had signs and symptoms of neuropathy and electrophysiologic abnormalities. The clinical and subclinical groups correlated with increased content of arsenic in urine, hair and nails. The incidence of subclinical and clinical neuropathy was greater in arsenic workers than in unexposed controls.
我们对一家铜冶炼厂中接触三氧化二砷的个体进行了一项双盲对照研究。受试者分为三类周围神经病变：无、亚临床和临床。亚临床组没有麻木或反射减弱的症状或体征，但神经传导速度和波幅测量值降低。临床神经病变组有神经病变的症状和体征以及电生理异常。临床组和亚临床组与尿、头发和指甲中砷含量增加相关。砷作业工人中亚临床和临床神经病变的发生率高于未接触者对照组。
