Nayak Meghanand T, Singh Anjali, Mathur Rm, Wadhwani Puneet
Department of Oral and Maxillofacial Pathology, Saraswati Dental College and Hospital, Lucknow, India.
J Oral Maxillofac Pathol. 2012 Jan;16(1):88-90. doi: 10.4103/0973-029X.92980.
Melanomas are neoplasms of melanocytic origin. They are aggressive neoplasms with an unpredictable behavior, and can involve virtually any organ of the body. Oral melanomas are very rare and have an extremely poor prognosis. Early diagnosis and prompt treatment is the key to reduce the morbidity and mortality. A second primary tumor is a new primary tumor developing in a person with a history of tumor, in a new site or tissue and subsequent to the initial tumor. Patients with previous history of melanoma are associated with a higher risk of developing second primaries. A case of second primary oral melanoma in a 55-year-old female is reported here. The anachronistic presentation of the primary and the second primary lesions make this case clinically interesting. Noteworthy immunohistochemical findings were recorded, HMB-45 positive and S-100 negative.
黑色素瘤是黑素细胞起源的肿瘤。它们是具有不可预测行为的侵袭性肿瘤，几乎可累及身体的任何器官。口腔黑色素瘤非常罕见，预后极差。早期诊断和及时治疗是降低发病率和死亡率的关键。第二原发性肿瘤是指在有肿瘤病史的患者中，于新的部位或组织中在初始肿瘤之后发生的新原发性肿瘤。有黑色素瘤既往史的患者发生第二原发性肿瘤的风险更高。本文报道一例55岁女性的第二原发性口腔黑色素瘤病例。原发性和第二原发性病变的非同步表现使该病例在临床上很有意思。记录到了值得注意的免疫组化结果，HMB-45阳性而S-100阴性。
