Mosbah Amira A Abd El-Rahman, Abd-Ellatif Nahla A Bahgat, Sorour Ehab Ibrahim, El-Halaby Alaa F
Department of Pediatric, Faculty of Medicine, Cairo University, Cairo, Egypt.
J Egypt Soc Parasitol. 2011 Dec;41(3):745-52.
The placental alkaline phosphatase (PAP) activity progressively rises as pregnancy advances, possibly, because of its increasing synthesis by placental tissue. The present study examined the relationship between placental alkaline phosphatase activity and the biochemical indices of foetal nutrition (cord blood glucose, albumin) and growth (neonatal birth weight). Placental and umbilical cord blood samples were collected from 56 term deliveries 30 of them were appropriate for gestational age (AGA) and 26 were small for gestational age(SGA) and prepared for placental alkaline phosphatase assay, glucose and albumin estimations using standard procedures. The birth weights of the neonates at term were taken and recorded. Correlation analyses of the data obtained show significant positive relationships between PAP and cord blood glucose, albumin and birth weight in AGA newborn (r2 = 0.86, 0.71, 0.68 p<0.05) and (r2 = 0.69, 0.81, 0.73 p<0.05) in SGA newborn but no significant relationship with gestational age, also there was significant statistical difference between both groups in level of PAP, glucose and albumin.
胎盘碱性磷酸酶（PAP）活性随着孕期推进而逐渐升高，这可能是因为胎盘组织对其合成增加。本研究探讨了胎盘碱性磷酸酶活性与胎儿营养生化指标（脐血葡萄糖、白蛋白）及生长指标（新生儿出生体重）之间的关系。从56例足月分娩中采集胎盘和脐血样本，其中30例为适于胎龄儿（AGA），26例为小于胎龄儿（SGA），并采用标准程序准备进行胎盘碱性磷酸酶测定、葡萄糖和白蛋白检测。记录足月新生儿的出生体重。对所得数据进行的相关性分析显示，AGA新生儿中PAP与脐血葡萄糖、白蛋白及出生体重之间存在显著正相关（r2 = 0.86、0.71、0.68，p<0.05），SGA新生儿中PAP与脐血葡萄糖、白蛋白及出生体重之间也存在显著正相关（r2 = 0.69、0.81、0.73，p<0.05），但与胎龄无显著相关性，两组在PAP、葡萄糖和白蛋白水平上也存在显著统计学差异。
