Kingsley Karl
University of Nevada, Las Vegas, School of Dental Medicine, 1001 Shadow Lane, B315, Las Vegas, NV 89106, USA.
J Diet Suppl. 2010 Mar;7(1):51-9. doi: 10.3109/19390210903535019.
Folates are associated with a variety of human health benefits, while folate deficiency has been identified as a potential risk factor for many health problems and cancers, due to its role in dysregulation of DNA synthesis, repair and methylation. The US Food and Drug Administration adopted requirements for folate fortification in some food products, which has resulted in an increase in mean dietary folate intake and a concomitant reduction in the incidence of adverse health effects associated with folate deficiency. This includes a significant reduction in the incidence of folate deficiency-associated birth defects, such as spina bifida.
叶酸与多种对人类健康有益的方面相关，而叶酸缺乏已被认定为许多健康问题和癌症的潜在风险因素，这是因为它在DNA合成、修复和甲基化失调中所起的作用。美国食品药品监督管理局对某些食品制定了叶酸强化要求，这使得膳食中叶酸的平均摄入量有所增加，同时与叶酸缺乏相关的不良健康影响的发生率也随之降低。这包括与叶酸缺乏相关的出生缺陷（如脊柱裂）的发生率显著下降。
