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日本老年 2 型糖尿病患者的饮食模式与死亡率:富含蔬菜和鱼类的饮食是否能改善死亡率?一项解释性研究。

Dietary pattern and mortality in Japanese elderly patients with type 2 diabetes mellitus: does a vegetable- and fish-rich diet improve mortality? An explanatory study.

机构信息

Department of Biostatistics, School of Public Health, the University of Tokyo, Tokyo, Japan.

出版信息

Geriatr Gerontol Int. 2012 Apr;12 Suppl 1:59-67. doi: 10.1111/j.1447-0594.2011.00813.x.

DOI:10.1111/j.1447-0594.2011.00813.x
PMID:22435941
Abstract

AIM

To assess the effect of dietary patterns on all deaths and diabetes-related deaths in the Japanese Elderly Diabetes Intervention Trial (J-EDIT).

METHODS

We investigated relationships between that of overall mortality and dietary pattern, and diabetes-related deaths and dietary pattern as observed among 912 registered cases of the J-EDIT study, which is a prospective follow-up study of elderly Japanese type 2 diabetic patients.

RESULTS

Factor analysis with the factor number 3 led to deriving three dietary patterns (healthy type, snack type and greasy type). The relationship between these patterns and overall mortality or diabetes-related death was investigated. Although not statistically significant, there was a lower tendency of overall mortality and diabetes-related deaths for the healthy type dietary pattern. When the tendencies of overall mortality were analyzed for "young-old," who are younger than 75 years-of age, and "old-old" of over 75 years-of-age, the mortality rate for the greasy type and healthy type dietary patterns were nearly the same and higher than the snack type dietary pattern in young-old. In contrast, in old-old, a higher mortality rate was reported for the greasy type dietary pattern and a lower mortality rate was reported for the healthy type dietary pattern. The hazard ratio by Cox regression analysis for greasy type to healthy type in old-old was 3.03 (P = 0.04, CI 1.07-8.57). Furthermore, in old-old, as vegetable consumption increased, the lower the tendency foroverall mortality, and the more fish that was consumed, the overall mortality significantly decreased (P = 0.020) in the tertile.

CONCLUSIONS

The greasy type dietary pattern with an increased amount of sugar, fat and meat led to poor life prognosis for elderly Japanese type 2 diabetic patients. The healthy type dietary pattern rich in vegetable and fish, which is similar to the Mediterranean diet and Dietary Approach to Stop Hypertension diet, was suggested to improve life prognosis.

摘要

目的

评估饮食模式对日本老年糖尿病干预试验(J-EDIT)中全因死亡和糖尿病相关死亡的影响。

方法

我们对 J-EDIT 研究中 912 例注册病例的整体死亡率与饮食模式之间的关系以及糖尿病相关死亡与饮食模式之间的关系进行了研究,该研究是一项对日本老年 2 型糖尿病患者的前瞻性随访研究。

结果

通过因子分析得出 3 个因子,得出 3 种饮食模式(健康型、零食型和油腻型)。研究了这些模式与全因死亡率或糖尿病相关死亡率的关系。虽然没有统计学意义,但健康型饮食模式的全因死亡率和糖尿病相关死亡率有较低的趋势。当分析“年轻老年人”(年龄小于 75 岁)和“年老老年人”(年龄大于 75 岁)的全因死亡率趋势时,油腻型和健康型饮食模式的死亡率与零食型饮食模式相近,且在年轻老年人中较高。相比之下,在年老老年人中,油腻型饮食模式的死亡率较高,健康型饮食模式的死亡率较低。Cox 回归分析中油腻型与健康型在年老老年人中的风险比为 3.03(P=0.04,CI 1.07-8.57)。此外,在年老老年人中,随着蔬菜摄入量的增加,全因死亡率的趋势越低,鱼类摄入量越高,全因死亡率显著降低(P=0.020)。

结论

富含糖、脂肪和肉类的油腻型饮食模式导致日本老年 2 型糖尿病患者的预后不良。富含蔬菜和鱼类的健康型饮食模式与地中海饮食和停止高血压的饮食方法相似,可改善预后。

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