Grenier J F, Marescaux J, Michel F, Sava G, Kachelhoffer J
Nouv Presse Med. 1979 Apr 21;8(18):1505-8.
An early diagnosis of the Verner-Morrison syndrome will greatly enhance the chances of curative resection. There is a striking need for a simple diagnostic test. A number of suggestions have been made for the presumed hormone mediator of this syndrome. Numerous reports have led to a wide acceptance that vasoactive intestinal peptide (VIP) is the responsible mediator for the pharmacologic actions of this peptide are similar to the physiological characteristics noted in the watery diarrhea syndrome. A raised plasma VIP concentration, on the other hand, would suggest the presence of a tumour. These observations argue for the radioimmunoassay measurement of plasma VIP in a patient with the watery diarrhea syndrome.
早期诊断韦纳-莫里森综合征将大大提高根治性切除的几率。迫切需要一种简单的诊断测试。对于该综合征假定的激素介质，已经提出了一些建议。大量报告使人们广泛接受血管活性肠肽（VIP）是该综合征药理作用的介导物，因为这种肽的药理作用与水样腹泻综合征中所观察到的生理特征相似。另一方面，血浆VIP浓度升高提示存在肿瘤。这些观察结果支持对患有水样腹泻综合征的患者进行血浆VIP的放射免疫测定。
