β-肾上腺素能拮抗剂与三环类抗抑郁药的联合使用：一项初步研究。

Coadministration of a beta-adrenergic antagonist and a tricyclic antidepressant: a pilot study.

作者信息

Tang S W, Remington G, Persad E, Rosenblat R

机构信息

Clinical Psychopharmacology Unit, Clarke Institute of Psychiatry, Toronto, Ont., Canada.

出版信息

Psychiatry Res. 1990 Aug;33(2):101-6. doi: 10.1016/0165-1781(90)90062-a.

DOI:10.1016/0165-1781(90)90062-a

PMID:2243886

Abstract

After a 7-day washout period, 16 subjects suffering from unipolar depression were randomly assigned to either desipramine (DMI) or DMI plus propranolol treatment for 21 days. Both groups showed a significant improvement in their scores on the Hamilton Rating Scale for Depression (HRSD) after 21 days of drug treatment. However, there was no significant difference in the improvement in HRSD scores between the two groups. The results of this pilot study support the need to reevaluate the popular belief that propranolol induces or worsens depression.

摘要

在为期7天的洗脱期后，16名患有单相抑郁症的受试者被随机分配接受去甲丙咪嗪（DMI）或DMI加普萘洛尔治疗21天。两组在药物治疗21天后，汉密尔顿抑郁评定量表（HRSD）得分均有显著改善。然而，两组之间HRSD得分的改善情况并无显著差异。这项初步研究的结果支持了重新评估普萘洛尔会诱发或加重抑郁症这一普遍观点的必要性。