Overstreet D H, Dilsaver S C, Janowsky D S, Rezvani A H
School of Biological Sciences, Flinders University of South Australia.
Psychiatry Res. 1990 Aug;33(2):139-50. doi: 10.1016/0165-1781(90)90068-g.
The Flinders Sensitive Line (FSL) was derived from the Sprague-Dawley rat by selectively breeding those animals exhibiting a high level of sensitivity to an anticholinesterase. The Flinders Resistant Line (FRL) was simultaneously developed as a control line. These lines exhibit nonoverlapping distributions of their thermic responsiveness to oxotremorine. Bright light prevents the development of supersensitivity to oxotremorine occurring as a result of forced stress or treatment with a muscarinic receptor antagonist in the rat. The authors now report that treatment with bright light during the regular photoperiod (i.e., a time that does not produce a phase-shift or free-running) differentially affects the hypothermic response and activity-suppressing effect of oxotremorine in both the FSL and FRL. Both lines exhibit decreased hypothermia without reduction in motor activity in response to oxotremorine following 6 days of treatment with bright light. The magnitude of blunting of the hypothermic response was greater in the FSL than the FRL. These findings suggest that (1) studies of the effects of bright light are contingent on the end point one measures and (2) the capacity of this treatment to blunt the hypothermic response to a muscarinic agonist is greater in an animal model with endogenously hyperactive muscarinic cholinergic systems.
弗林德斯敏感品系（FSL）是通过选择性培育对抗胆碱酯酶表现出高度敏感性的动物，从斯普拉格-道利大鼠中衍生而来。弗林德斯抗性品系（FRL）作为对照品系同时培育而成。这些品系对氧震颤素的热反应性呈现不重叠的分布。强光可阻止大鼠因强制应激或用毒蕈碱受体拮抗剂处理而出现的对氧震颤素超敏反应的发展。作者现报告，在正常光周期（即不产生相移或自由运转的时间）期间用强光处理，对FSL和FRL中氧震颤素的体温过低反应和活动抑制作用有不同影响。在用强光处理6天后，两个品系对氧震颤素的反应均表现为体温过低减轻而运动活动无减少。FSL中体温过低反应减弱的程度大于FRL。这些发现表明：（1）对强光作用的研究取决于所测量的终点；（2）在具有内源性毒蕈碱胆碱能系统功能亢进的动物模型中，这种处理减弱对毒蕈碱激动剂体温过低反应的能力更强。
