抑郁症和精神分裂症患者对生长激素释放激素的生长激素反应。

Growth hormone response to growth hormone releasing hormone in depression and schizophrenia.

作者信息

Peabody C A, Warner M D, Markoff E, Hoffman A R, Wilson D M, Csernansky J G

机构信息

Department of Psychiatry, University of Texas, Houston.

出版信息

Psychiatry Res. 1990 Sep;33(3):269-76. doi: 10.1016/0165-1781(90)90043-5.

DOI:10.1016/0165-1781(90)90043-5

PMID:2243902

Abstract

Growth hormone releasing hormone, a 44-amino acid peptide (GHRH-44), was administered (1 micrograms/kg i.v.) to 6 normal controls, 10 schizophrenic subjects, and 7 depressed subjects. A significantly lower growth hormone (GH) response was found in the schizophrenic and depressed groups. Two molecular forms of GH, 22K GH and 20K GH, were also measured but did not further differentiate the three groups of subjects.

摘要

向6名正常对照者、10名精神分裂症患者和7名抑郁症患者静脉注射生长激素释放激素（一种44个氨基酸的肽，GHRH - 44），剂量为1微克/千克。结果发现，精神分裂症组和抑郁症组的生长激素（GH）反应显著较低。还检测了两种分子形式的生长激素，即22K GH和20K GH，但这并没有进一步区分这三组受试者。