Vigneron D B, Nelson S J, Murphy-Boesch J, Kelley D A, Kessler H B, Brown T R, Taylor J S
Department of NMR and Medical Spectroscopy, Fox Chase Cancer Center, Philadelphia, Pa.
Radiology. 1990 Dec;177(3):643-9. doi: 10.1148/radiology.177.3.2243963.
Multivoxel magnetic resonance (MR) spectroscopy and novel data analysis techniques were developed to obtain high-quality phosphorus-31 metabolite images from the human brain and to overlay each metabolite distribution directly onto corresponding hydrogen-1 MR images. The P-31 MR spectroscopic data were acquired by means of three-dimensional chemical shift imaging (phase encoding in three spatial dimensions) on a 1.5-T clinical instrument equipped with a specially designed quadrature P-31 birdcage coil constructed in the authors' laboratory. Axial, sagittal, and coronal metabolite images based on the area for any one of five peak regions (phosphodiester; phosphocreatine; gamma, alpha, and beta adenosine triphosphate) were generated from 8 X 8 X 8 or 12 X 12 X 8 CSI arrays with voxel sizes of 27 cm3 and 12 cm3, respectively. The positions of these images were aligned with anatomic features by means of the voxel-shifting capability of the Fourier transform. Direct overlays of these metabolite images on corresponding proton images demonstrated excellent correlation with anatomy, factors indicating the utility of this technique for viewing P-31 metabolite levels in all areas of the brain simultaneously.
开发了多体素质子磁共振（MR）波谱技术和新型数据分析技术，以从人脑获取高质量的磷-31代谢物图像，并将每种代谢物分布直接叠加到相应的氢-1 MR图像上。磷-31 MR波谱数据是在一台1.5-T临床仪器上通过三维化学位移成像（在三个空间维度上进行相位编码）采集的，该仪器配备了作者实验室特制的正交磷-31鸟笼式线圈。基于五个峰区（磷酸二酯；磷酸肌酸；γ、α和β三磷酸腺苷）中任一峰区面积的轴向、矢状和冠状代谢物图像，分别由体素大小为27 cm3和12 cm3的8×8×8或12×12×8化学位移成像（CSI）阵列生成。这些图像的位置通过傅里叶变换的体素移位功能与解剖特征对齐。这些代谢物图像在相应质子图像上的直接叠加显示出与解剖结构的良好相关性，这表明该技术可用于同时观察大脑所有区域的磷-31代谢物水平。
