梭曼对兔主动脉钙内流的影响。

Effects of soman on calcium influx into rabbit aorta.

作者信息

Hsu C H, Hu C Y, Robinson C P

机构信息

College of Pharmacy, University of Oklahoma, Oklahoma City 73190.

出版信息

Toxicol Lett. 1990 Nov;54(1):33-7. doi: 10.1016/0378-4274(90)90052-n.

DOI:10.1016/0378-4274(90)90052-n

PMID:2244338

Abstract

The acute addition of 10 microM soman to rabbit aorta rings did not increase resting 45Ca2+ influx significantly in the absence or presence of 10 microM norepinephrine or 80 mM potassium (P greater than 0.05). However, agonist-induced 45Ca2+ influx into aorta rings from rabbits that received soman daily for 7 days was significantly reduced (P less than 0.05) compared to agonist-induced influx into rings from control rabbits. The resting influx of 45Ca2+ into aorta rings from 7 day soman-treated and control rabbits was not different (P greater than 0.05). The depression by soman of norepinephrine- and K(+)-induced 45Ca2+ influx may be due to adaptive changes resulting from the 7-day administration of soman.

摘要

在不存在或存在10微摩尔去甲肾上腺素或80毫摩尔钾的情况下，向兔主动脉环急性添加10微摩尔梭曼不会显著增加静息状态下的45Ca2+内流（P>0.05）。然而，与激动剂诱导对照兔主动脉环的45Ca2+内流相比，连续7天每日接受梭曼处理的兔主动脉环中，激动剂诱导的45Ca2+内流显著减少（P<0.05）。来自连续7天接受梭曼处理的兔和对照兔的主动脉环的静息45Ca2+内流没有差异（P>0.05）。梭曼对去甲肾上腺素和钾诱导的45Ca2+内流的抑制作用可能是由于7天给予梭曼所导致的适应性变化。