Yoshimura H
National Veterinary Assay Laboratory, Tokyo, Japan.
Toxicol Lett. 1990 Nov;54(1):55-9. doi: 10.1016/0378-4274(90)90055-q.
Diminazene diaceturate was dissolved in deionized water and administered to pregnant rats by oral gavage once daily on days 8-15 of pregnancy at dose levels of 0, 100, 250, 500 and 1000 mg/kg. On day 21 of pregnancy, the dams were killed and the number of implants, resorptions and live fetuses counted. All fetuses were examined by routine teratological method. A significant increase in fetal resorptions and decrease in fetal body weights were found at the 1000 mg/kg dose. No significant increase in the incidence of anomalous fetuses was observed in external, skeletal and internal examinations even at the maternally toxic dose of 1000 mg/kg. Thus, these data indicate that diminazene diaceturate is not teratogenic in rats.
将双乙酰氨苯脒溶解于去离子水中，在妊娠第8至15天，以0、100、250、500和1000毫克/千克的剂量水平，通过口服灌胃法给予怀孕大鼠。在妊娠第21天，处死母鼠，计算着床数、吸收数和活胎数。所有胎儿均采用常规致畸学方法检查。在1000毫克/千克剂量组，发现胎儿吸收显著增加，胎儿体重下降。即使在1000毫克/千克的母体毒性剂量下，在外部、骨骼和内部检查中也未观察到畸形胎儿发生率显著增加。因此，这些数据表明双乙酰氨苯脒对大鼠无致畸性。
