Darke Shane, Deady Mark, Duflou Johan
National Drug and Alcohol Research Centre, University of New South Wales, NSW, Sydney, Australia.
J Forensic Sci. 2012 Sep;57(5):1259-62. doi: 10.1111/j.1556-4029.2012.02117.x. Epub 2012 Mar 23.
All cases presenting to the New South Wales Department of Forensic Medicine between January 1, 2001 and September 31, 2010 in which zolpidem was detected, were retrieved. A total of 91 cases were identified. The mean age was 49.4 years, 65.9% were male, and 61.5% were suicides. Zolpidem was a factor contributing to death in 35 (37.3%) cases, of which 31 (34.1%) involved zolpidem toxicity. The median blood zolpidem concentration was 0.20 mg/L (range 0.05-3.50 mg/L), with no significant gender difference. Drug toxicity cases involving zolpidem had significantly higher median blood zolpidem concentrations than other cases (0.50 vs. 0.10 mg/L). In 83.5% of cases, psychoactive substances other than zolpidem were detected, most commonly antidepressants (46.2%), benzodiazepines (35.2%), opioids (26.4%), and alcohol (39.6%). In summary, zolpidem was a factor contributing to death in a large proportion of cases, predominately involving drug toxicity and suicide.
检索了2001年1月1日至2010年9月31日期间向新南威尔士法医部报告的所有检测到唑吡坦的病例。共识别出91例。平均年龄为49.4岁，65.9%为男性，61.5%为自杀。唑吡坦是35例（37.3%）死亡的一个促成因素，其中31例（34.1%）涉及唑吡坦中毒。唑吡坦血药浓度中位数为0.20mg/L（范围0.05 - 3.50mg/L），无显著性别差异。涉及唑吡坦的药物中毒病例的唑吡坦血药浓度中位数显著高于其他病例（0.50对0.10mg/L）。在83.5%的病例中，检测到除唑吡坦外的精神活性物质，最常见的是抗抑郁药（46.2%）、苯二氮䓬类药物（35.2%）、阿片类药物（26.4%）和酒精（39.6%）。总之，唑吡坦在很大一部分病例中是导致死亡的一个因素，主要涉及药物中毒和自杀。
