Darke Shane, Duflou Johan, Torok Michelle
National Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW 2052, Australia.
J Forensic Sci. 2011 May;56(3):690-3. doi: 10.1111/j.1556-4029.2011.01703.x. Epub 2011 Mar 1.
All cases of fatal oxycodone toxicity presenting to the New South Wales Department of Forensic Medicine over the period January 1, 1999, to December 31, 2008, were retrieved. A total of 70 cases were identified. The mean age was 48.9 years, 58.6% were men, 21.4% were suicides, and in 30% oxycodone had not been prescribed to the decedent. Injecting drug users constituted 27.1% of cases, and oxycodone tablets were injected immediately prior to death by 21.4%. The mean blood oxycodone concentration was 0.40 mg/L (range 0.06-53.00 mg/L). In all cases, psychoactive substances other than oxycodone were also detected, most frequently hypnosedatives (68.6%), other opioids (54.3%), antidepressants (41.4%), and alcohol (32.9%). Preexisting systemic disease was common: cardiovascular (64.2%), pulmonary (49.3%), hepatic (66.7%), and renal (43.9%).
检索了1999年1月1日至2008年12月31日期间新南威尔士法医部接收的所有致命性羟考酮中毒病例。共识别出70例。平均年龄为48.9岁，58.6%为男性，21.4%为自杀，30%的死者未被开具过羟考酮处方。注射吸毒者占病例的27.1%，21.4%的病例在死亡前立即注射了羟考酮片。血液中羟考酮的平均浓度为0.40 mg/L（范围为0.06 - 53.00 mg/L）。在所有病例中，还检测到了除羟考酮以外的精神活性物质，最常见的是催眠镇静剂（68.6%）、其他阿片类药物（54.3%）、抗抑郁药（41.4%）和酒精（32.9%）。既往存在全身性疾病很常见：心血管疾病（64.2%）、肺部疾病（49.3%）、肝脏疾病（66.7%）和肾脏疾病（43.9%）。
