Pietribiasi F, Sapino A, Papotti M, Bussolati G
Department of Biomedical Sciences and Human Oncology, University of Turin, Torino, Italy.
Am J Clin Pathol. 1990 Dec;94(6):687-92. doi: 10.1093/ajcp/94.6.687.
The authors report on the cytologic features of six cases of poorly differentiated "insular" carcinoma (IC) of the thyroid, a recently described variety of thyroid tumor intermediate between well-differentiated and anaplastic neoplasms. It is characterized by trabecular and/or alveolar growth patterns, merging with follicular areas, and by the absence of pleomorphism in the tumor cells. Fine-needle aspiration biopsy (FNAB) materials (both smears and cell-block preparations) from six patients were reviewed after the diagnosis of IC was confirmed on the surgical specimen. The following cytologic features were consistently found: high cellularity and necrotic background; low grade of atypia; trabeculae and/or clusters, possibly associated with microfollicles, of cells with poorly defined cytoplasm; and cytoplasmic vacuoles containing thyroglobulin. Nuclear inclusions and grooving of the nuclear surface were additional features. Preoperative diagnosis suggestive of IC might be of value for planning surgical treatment and subsequent therapy.
作者报告了6例甲状腺低分化“岛状”癌（IC）的细胞学特征，这是一种最近描述的甲状腺肿瘤，介于高分化和间变性肿瘤之间。其特征为小梁状和/或腺泡状生长模式，与滤泡区域融合，且肿瘤细胞无多形性。在手术标本确诊为IC后，对6例患者的细针穿刺活检（FNAB）材料（涂片和细胞块标本）进行了复查。 consistently发现以下细胞学特征：细胞丰富且背景坏死；异型性程度低；小梁状和/或细胞簇，可能与微滤泡有关，细胞胞质界限不清；以及含有甲状腺球蛋白的胞质空泡。核内包涵体和核表面沟纹是其他特征。术前诊断提示IC可能对规划手术治疗和后续治疗有价值。
