Kojima Daisuke, Hatai Hitoshi, Oyamada Toshifumi, Park Chun-Ho
Department of Veterinary Pathology, School of Veterinary Medicine, Kitasato University, 23-35-1 Higashi, Towada, Aomori 034-8628, Japan.
J Vet Med Sci. 2012 Aug;74(8):1045-9. doi: 10.1292/jvms.11-0555. Epub 2012 Mar 22.
Extraskeletal myxoid chondrosarcoma was found in a five-month-old male Irish setter dog. At necropsy, the largest mass, measuring 15 × 13 × 13 cm, was found in the right caudal lobe of the lung, and metastatic small masses were observed in multiple organs. Microscopically, the tumor comprised mainly atypical mesenchymal cells and myxoid stroma, which stained positively with Alcian blue. Immunohistochemically, the tumor cells stained positively for vimentin, S-100 protein, neuron-specific enolase, calretinin, and chromogranin A. Ultrastructurally, the cytoplasm of the tumor cells was comprised abundant rough endoplasmic reticulum, mitochondria, Golgi complex, free ribosomes and short irregular microvillous processes extending from the cytoplasm. Based on these pathological findings, this tumor was diagnosed as extraskeletal myxoid chondrosarcoma.
在一只5个月大的雄性爱尔兰雪达犬身上发现了骨外黏液样软骨肉瘤。尸检时，在右肺尾叶发现最大的肿块，大小为15×13×13厘米，并在多个器官中观察到转移性小肿块。显微镜下，肿瘤主要由非典型间充质细胞和黏液样基质组成，阿尔辛蓝染色呈阳性。免疫组织化学检查显示，肿瘤细胞波形蛋白、S-100蛋白、神经元特异性烯醇化酶、钙视网膜蛋白和嗜铬粒蛋白A染色呈阳性。超微结构上，肿瘤细胞的细胞质含有丰富的粗面内质网、线粒体、高尔基体、游离核糖体以及从细胞质伸出的短而不规则的微绒毛状突起。基于这些病理结果，该肿瘤被诊断为骨外黏液样软骨肉瘤。
