Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Circ J. 2012;76(6):1415-22. doi: 10.1253/circj.cj-11-1481. Epub 2012 Mar 15.
In order to achieve target blood pressure levels to prevent cardiovascular disease, combination therapy of antihypertensive drugs is often required, although it is thought that requiring a patient to take many different pills would reduce adherence to the medication regimen. Whether antihypertensive treatment with a single pill combining antihypertensive drugs would improve medication adherence and blood pressure control was investigated.
A total of 207 hypertensive subjects were randomly assigned to a combination pill group (losartan 50mg/hydrochlorothiazide 12.5mg; n=103) or a control group (an angiotensin receptor blocker and a thiazide diuretic; n=104). Medication adherence was evaluated by pill counts at 1, 3, and 6 months after randomization. The mean adherence rates over 6 months were not different between the 2 groups: 98% in the combination pill group and 98% in the control group. Moreover, the 2 groups included similar numbers of subjects with relatively poor adherence rates (<90%) in each treatment period. The mean blood pressures over the 6-month treatment period were not different between the groups: 131/75 mmHg in the combination pill group and 130/75 mmHg in the control group (P=0.84/0.96).
There were no appreciable effects of the combination pill of antihypertensive drugs on medication adherence or blood pressure control in Japanese patients over a 6-month period.
为了达到预防心血管疾病的目标血压水平，通常需要联合应用降压药物进行治疗，尽管人们认为让患者服用多种不同的药物会降低对药物治疗方案的依从性。因此，研究了用包含降压药物的单片复方制剂治疗高血压是否可以提高药物依从性和血压控制。
共 207 例高血压患者被随机分为联合片剂组（氯沙坦 50mg/氢氯噻嗪 12.5mg；n=103）或对照组（血管紧张素受体阻滞剂和噻嗪类利尿剂；n=104）。在随机分组后 1、3 和 6 个月时通过计算药片数评估药物依从性。6 个月的平均药物依从率在两组间无差异：联合片剂组为 98%，对照组为 98%。此外，在每个治疗期间，两组均包括相对依从性较差（<90%）的相似数量的患者。6 个月治疗期间的平均血压在两组间无差异：联合片剂组为 131/75mmHg，对照组为 130/75mmHg（P=0.84/0.96）。
在日本患者中，使用包含降压药物的单片复方制剂治疗 6 个月对药物依从性或血压控制没有明显影响。
