Malchenko Sergey, Seftor Elisabeth A, Nikolsky Yuri, Hasegawa Susan L, Kuo Sean, Stevens Jeff W, Poyarkov Stas, Nikolskaya Tatiana, Kucaba Tamara, Wang Min, Abdulkawy Hakim, Casavant Thomas, Morcuende Jose, Buckwalter Joseph, Hohl Raymond, Deyoung Barry, Kernstine Kemp, Bonaldo Maria de Fatima, Hendrix Mary J C, Soares Marcelo B, Soares Vera Maria F C
Cancer Biology and Epigenomics Program, Children's Memorial Research Center, and Department of Pediatrics, Northwestern University Feinberg School of Medicine, 2430 N. Halstead Street, Chicago, IL 60614, USA.
Sarcoma. 2012;2012:820254. doi: 10.1155/2012/820254. Epub 2012 Feb 16.
Chondrosarcomas are among the most malignant skeletal tumors. Dedifferentiated chondrosarcoma is a highly aggressive subtype of chondrosarcoma, with lung metastases developing within a few months of diagnosis in 90% of patients. In this paper we performed comparative analyses of the transcriptomes of five individual metastatic lung lesions that were surgically resected from a patient with dedifferentiated chondrosarcoma. We document for the first time a high heterogeneity of gene expression profiles among the individual lung metastases. Moreover, we reveal a signature of "multifunctional" genes that are expressed in all metastatic lung lesions. Also, for the first time, we document the occurrence of massive macrophage infiltration in dedifferentiated chondrosarcoma lung metastases.
软骨肉瘤是最恶性的骨骼肿瘤之一。去分化软骨肉瘤是软骨肉瘤的一种高度侵袭性亚型，90%的患者在诊断后几个月内就会发生肺转移。在本文中，我们对一名去分化软骨肉瘤患者手术切除的五个转移性肺病变的转录组进行了比较分析。我们首次记录了各个肺转移灶之间基因表达谱的高度异质性。此外，我们揭示了在所有转移性肺病变中均表达的“多功能”基因特征。同样，我们首次记录了去分化软骨肉瘤肺转移灶中大量巨噬细胞浸润的发生情况。
