对血管生成素在肌动蛋白聚合中的作用的新认识。
New insights into the role of angiogenin in actin polymerization.
机构信息
Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
出版信息
Int Rev Cell Mol Biol. 2012;295:175-98. doi: 10.1016/B978-0-12-394306-4.00011-3.
Abstract
Angiogenin is a potent stimulator of angiogenesis. It interacts with endothelial cells and induces a wide range of cellular responses initiating a process of blood vessel formation. One important target of angiogenin is endothelial cell-surface actin, and their interaction might be one of crucial steps in angiogenin-induced neovascularization. Recently, it was shown that angiogenin inhibits polymerization of G-actin and changes the physical properties of F-actin. These observations suggest that angiogenin may cause changes in the cell cytoskeleton. This chapter reviews the current state of the literature regarding angiogenin structure and function and discusses the relationship between the angiogenin and actin and possible functional roles of their interaction.
摘要
血管生成素是一种强有力的血管生成刺激因子。它与内皮细胞相互作用，并诱导广泛的细胞反应，启动血管形成过程。血管生成素的一个重要靶标是内皮细胞表面的肌动蛋白，它们的相互作用可能是血管生成素诱导新生血管形成的关键步骤之一。最近，研究表明血管生成素抑制 G 肌动蛋白的聚合，并改变 F 肌动蛋白的物理性质。这些观察结果表明，血管生成素可能导致细胞细胞骨架发生变化。本章综述了关于血管生成素结构和功能的文献现状，并讨论了血管生成素与肌动蛋白之间的关系及其相互作用的可能功能作用。
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New insights into the role of angiogenin in actin polymerization.对血管生成素在肌动蛋白聚合中的作用的新认识。
Int Rev Cell Mol Biol. 2012;295:175-98. doi: 10.1016/B978-0-12-394306-4.00011-3.
2
Binding of human angiogenin inhibits actin polymerization.人血管生成素抑制肌动蛋白聚合。
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[Angiogenin and its role in angiogenesis].[血管生成素及其在血管生成中的作用]
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Actin is a binding protein for angiogenin.肌动蛋白是血管生成素的一种结合蛋白。
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Regulation of actin cytoskeleton dynamics in cells.细胞中肌动蛋白细胞骨架动力学的调节。
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Angiogenin cleaves tRNA and promotes stress-induced translational repression.血管生成素切割转运RNA并促进应激诱导的翻译抑制。
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Kaposi's sarcoma-associated herpesvirus upregulates angiogenin during infection of human dermal microvascular endothelial cells, which induces 45S rRNA synthesis, antiapoptosis, cell proliferation, migration, and angiogenesis.卡波西肉瘤相关疱疹病毒在感染人真皮微血管内皮细胞期间上调血管生成素，这会诱导45S核糖体RNA合成、抗凋亡、细胞增殖、迁移和血管生成。
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