Universidade Federal Fluminense, Niterói, RJ, Brazil.
Arq Bras Cardiol. 2012 May;98(5):398-405. doi: 10.1590/s0066-782x2012005000027. Epub 2012 Mar 27.
Heart Rate Recovery (HRR) reflects the capacity of the cardiovascular system to reverse the vagal withdrawal caused by exercise. Scintigraphy with metaiodobenzylguanidine (I(123) MIBG) evaluates innervation and cardiac adrenergic activation. The association of these two methods is not well established.
To evaluate the association between HRR and washout rate (WO) of I(123) MIBG in patients with heart failure (HF).
Twenty-five patients with ejection fraction < 45% underwent exercise testing, and analysis of the variation of HRR from the 1st to the 8th minute after exertion. Submitted to I(123) MIBG, they were separated into groups by WO: G1) <27% and G2) ≥ 27%. For the statistical analysis Mann-Whitney's U test and Spearman's correlation coefficient were used.
G2 showed a slower variation of HRR: 1st minute: G1: 21.5 (16.12 to 26.87) vs. G2: 11.00 (8.5 to 13.5) bpm, p = 0.001; 2nd minute: G1: 34 (29-39) vs. G2: 20 (14 - 26) bpm, p = 0.001; 3rd minute: G1: 46 (37.8 - 54.1) vs. G2: 30 (22 - 38) bpm, p = 0.005; 5th minute: G1: 51.5 (42 - 61) vs. G2: 39 (31.5 to 46.5) bpm, p = 0.013, and in the 8th minute: G1: 54.5 (46.5 - 62.5) vs. G2: 43 (34 - 52) bpm, p = 0.037. HRR in the 1st (r = -0.555, p = 0.004), and in the 2nd minute (r = -0.550, p = 0.004) were negatively correlated with WO.
Patients with high HF and WO showed an abnormal HRR compared with patients with normal WO. These findings suggest that adrenergic activation may influence the HRR.
心率恢复（HRR）反映了心血管系统逆转运动引起的迷走神经撤退的能力。使用碘-123 间位碘苄胍（I(123) MIBG）闪烁显像评估神经支配和心脏去甲肾上腺素激活。这两种方法的关联尚未得到很好的确定。
评估心力衰竭（HF）患者 HRR 与 I(123) MIBG 洗脱率（WO）之间的相关性。
25 名射血分数<45%的患者进行运动试验，并分析运动后第 1 至第 8 分钟 HRR 的变化。进行 I(123) MIBG 后，根据 WO 将患者分为两组：G1）<27%和 G2）≥27%。统计分析采用 Mann-Whitney U 检验和 Spearman 相关系数。
G2 的 HRR 变化较慢：第 1 分钟：G1：21.5（16.12 至 26.87）vs. G2：11.00（8.5 至 13.5）bpm，p=0.001；第 2 分钟：G1：34（29-39）vs. G2：20（14-26）bpm，p=0.001；第 3 分钟：G1：46（37.8-54.1）vs. G2：30（22-38）bpm，p=0.005；第 5 分钟：G1：51.5（42-61）vs. G2：39（31.5 至 46.5）bpm，p=0.013，第 8 分钟：G1：54.5（46.5-62.5）vs. G2：43（34-52）bpm，p=0.037。第 1 分钟（r=-0.555，p=0.004）和第 2 分钟（r=-0.550，p=0.004）的 HRR 与 WO 呈负相关。
HF 高且 WO 高的患者与 WO 正常的患者相比，HRR 异常。这些发现表明，去甲肾上腺素激活可能影响 HRR。
