Medical Faculty, Institute of Medical Psychology and Medical Sociology, University of Rostock, Rostock, Germany.
Appl Psychophysiol Biofeedback. 2012 Sep;37(3):187-93. doi: 10.1007/s10484-012-9193-2.
Cortical attention and habituation parameters are altered in patients suffering from tinnitus. The aim of the study was to quantify cortical attention and habituation parameters in tinnitus patients by recording the contingent negative variation (CNV) response and to correlate amplitudes of different CNV parameters with duration of disease. Twenty patients suffering from tinnitus (median: 44 years) and twenty age- and sex-matched healthy controls (median: 41 years) were tested by a CNV paradigm. We recorded overall CNV, initial CNV, and terminal CNV and calculated habituation slopes. All CNV parameters were Spearman-correlated with individual duration of disease. Highly significant between groups differences emerged in total (tinnitus: -8.4 uV vs. controls: -3.8 uV), initial (-11.2 vs. -6.0 uV), and terminal CNV (-11.9 vs. -6.5 uV) demonstrating higher negative amplitudes in tinnitus patients. Habituation differed in total and terminal CNV, indicating missing habituation in tinnitus patients. Overall CNV (ϱ = -.365) and initial CNV (ϱ = -.529) showed a medium Spearman correlation with duration of disease. We conclude that the correlation between duration of tinnitus and the initial CNV amplitudes indicates an altered state of cortical excitability that can also be observed in more negative CNV-amplitudes in tinnitus patients. We assume that this state indicates a chronicity process in tinnitus disease.
皮质注意和习惯化参数在耳鸣患者中发生改变。本研究的目的是通过记录条件负变（CNV）反应来量化耳鸣患者的皮质注意和习惯化参数，并将不同 CNV 参数的振幅与疾病持续时间相关联。我们使用 CNV 范式对 20 名耳鸣患者（中位数：44 岁）和 20 名年龄和性别匹配的健康对照者（中位数：41 岁）进行了测试。我们记录了总的 CNV、初始 CNV 和终末 CNV，并计算了习惯化斜率。所有 CNV 参数均与个体疾病持续时间进行 Spearman 相关分析。在总 CNV（耳鸣：-8.4uV 与对照：-3.8uV）、初始 CNV（-11.2 与-6.0uV）和终末 CNV（-11.9 与-6.5uV）方面，耳鸣患者的负向振幅更高，两组之间存在显著的组间差异，表明耳鸣患者存在缺失的习惯化。总 CNV 和终末 CNV 的习惯化存在差异，表明耳鸣患者的习惯化缺失。总的 CNV（ρ=-.365）和初始 CNV（ρ=-.529）与疾病持续时间具有中等 Spearman 相关性。我们的结论是，耳鸣持续时间与初始 CNV 振幅之间的相关性表明了皮质兴奋性的改变状态，这在耳鸣患者的更负向 CNV 振幅中也可以观察到。我们假设这种状态表明耳鸣疾病的慢性过程。
