Kropp P, Gerber W D
Department of Medical Psychology, University of Kiel, Germany.
Cephalalgia. 1993 Feb;13(1):37-41. doi: 10.1046/j.1468-2982.1993.1301037.x.
The aim of this study was to compare the habituation kinetics of contingent negative variation (CNV) between 12 migraineurs without aura and matched healthy controls. CNV was studied with a 3 sec interval between the warning stimulus (WS) and the imperative stimulus (IS). The data from (a) the total interval (WS-IS), (b) early component, and (c) late component were analyzed. During successive trials the habituation kinetics were determined using regression analysis. On CNV averaged over 32 trials, migraine patients had a significantly higher negativity in the total interval compared to controls. When sequential blocks of four trials were analyzed, the most significant finding in migraineurs was lack of habituation of the early CNV component. The present study indicates that a delayed habituation, rather than a general increased cortical activity, is responsible for the CNV abnormalities in migraine without aura. We suggest that migraineurs between attacks not only have a cortical hyperexcitability, but also a lack of cortical inhibition causing delayed habituation.
本研究的目的是比较12名无先兆偏头痛患者与相匹配的健康对照者之间关联性负变（CNV）的习惯化动力学。采用在警告刺激（WS）和指令刺激（IS）之间间隔3秒的方式研究CNV。分析了来自（a）总间隔（WS - IS）、（b）早期成分和（c）晚期成分的数据。在连续试验期间，使用回归分析确定习惯化动力学。在32次试验的平均CNV上，偏头痛患者在总间隔中的负性变化显著高于对照组。当分析四个试验的连续组块时，偏头痛患者最显著的发现是早期CNV成分缺乏习惯化。本研究表明，延迟习惯化而非普遍增加的皮质活动是无先兆偏头痛中CNV异常的原因。我们认为，发作间期的偏头痛患者不仅存在皮质兴奋性过高，还存在皮质抑制缺乏导致习惯化延迟。
