Costa A, Silvestrini R, Mezzanotte G, Vaglini M, Grignolio E, Clemente C, Cascinelli N
Oncologia Sperimentale C, Instituto Nazionale Tumori, Milan, Italy.
Br J Cancer. 1990 Nov;62(5):826-9. doi: 10.1038/bjc.1990.386.
The prognostic role of cell kinetics (expressed as 3H-thymidine labelling index, 3H-TdR LI) was assessed on 145 patients with pathologic stage II melanoma subjected only to therapeutic lymph node dissection. The 3H-TdR LI determined on metastatic nodes was related to relapse-free survival and to survival. In particular, 3-year relapse-free survival was significantly different from patients with slowly and rapidly proliferating melanomas (40% vs 22%, P = 0.007), and this finding was consistently found for overall survival (68% vs 46%, P = 0.007). Moreover, in patients with high 3H-TdR LI tumours, the risk of relapse and death within the first year from lymphadenectomy was two-fold that of patients with low 3H-TdR LI tumours. Multiple regression analysis showed that 3H-TdR LI retained its prognostic significance on relapse-free and on overall survival even when the number of involved nodes and type of nodal metastases were considered. Present findings suggest that 3H-TdR LI can contribute to select high-risk stage II melanoma patients.
对仅接受治疗性淋巴结清扫的145例病理分期为II期黑色素瘤患者评估了细胞动力学(以3H-胸腺嘧啶核苷标记指数,即3H-TdR LI表示)的预后作用。在转移淋巴结上测定的3H-TdR LI与无复发生存率和生存率相关。特别是,3年无复发生存率在黑色素瘤增殖缓慢和快速的患者之间有显著差异(40%对22%,P = 0.007),总生存率也有同样的发现(68%对46%,P = 0.007)。此外,在3H-TdR LI高的肿瘤患者中,淋巴结切除术后第一年内复发和死亡的风险是3H-TdR LI低的肿瘤患者的两倍。多元回归分析表明,即使考虑受累淋巴结数量和淋巴结转移类型,3H-TdR LI对无复发生存率和总生存率仍具有预后意义。目前的研究结果表明,3H-TdR LI有助于筛选高危II期黑色素瘤患者。