Tubiana M, Pejovic M H, Chavaudra N, Contesso G, Malaise E P
Int J Cancer. 1984 Apr 15;33(4):441-5. doi: 10.1002/ijc.2910330404.
A prospective study of the prognostic significance of the labelling index (LI) was undertaken in 1972. The LI of the primary tumor was measured consecutively on 128 patients with mammary carcinoma at the time of initial treatment, following in vitro incubation of specimens with tritiated thymidine. The follow-up for all patients has now extended over 10 years. Relapse-free survival and total survival are significantly higher in patients with a low LI. A multivariate analysis of the prognostic factors, carried out with Cox's model, showed that LI is the most predictive indicator with respect to survival. The size of the tumor is the second most predictive indicator, while histological grading and the number of involved lymph nodes are less predictive. These results strongly suggest that proliferative activity as assessed by LI is directly related to metastatic dissemination probability, independent of other prognostic factors.
1972年对标记指数（LI）的预后意义进行了一项前瞻性研究。在对128例乳腺癌患者进行初始治疗时，将标本与氚标记的胸腺嘧啶核苷进行体外培养后，连续测量原发性肿瘤的LI。所有患者的随访现已超过10年。LI低的患者无复发生存率和总生存率显著更高。用Cox模型对预后因素进行多变量分析表明，LI是关于生存的最具预测性的指标。肿瘤大小是第二大预测指标，而组织学分级和受累淋巴结数量的预测性较低。这些结果强烈表明，通过LI评估的增殖活性与转移扩散概率直接相关，独立于其他预后因素。
