Gore Mitchell R, Zanation Adam M
Department of Otolaryngology, Head, and Neck Surgery, University of North Carolina Hospitals, North Carolina.
Skull Base. 2011 Jan;21(1):1-6. doi: 10.1055/s-0030-1254406.
Esthesioneuroblastoma has a local recurrence rate of ∼30%, but no standard regimen for salvage of local recurrence has been established. We report data from 678 patients from series published since 1990, with a risk reduction analysis of salvage with surgery, radiation, or combined surgery and radiation therapy. We found a 28.5% rate of local recurrence after treatment, and a 42.6% rate of successful salvage with surgery, radiation, or combined treatment. The odds ratio for successful salvage, defined as disease-free survival for at least 1 year, was not significantly different for combined surgery and radiation versus surgery alone or radiation alone or for surgery alone versus radiation alone. The salvage odds ratio for combined surgery and radiation therapy versus radiation therapy alone, 3.5, approached, but did not reach statistical significance. This study reveals a reasonable rate of successful salvage of local esthesioneuroblastoma recurrence using surgery, radiation, or combined surgery and radiation.
嗅神经母细胞瘤的局部复发率约为30%，但尚未确立挽救局部复发的标准方案。我们报告了自1990年以来发表的系列研究中678例患者的数据，并对手术、放疗或手术联合放疗挽救治疗进行了风险降低分析。我们发现治疗后局部复发率为28.5%，手术、放疗或联合治疗的成功挽救率为42.6%。定义为无病生存至少1年的成功挽救的优势比，手术联合放疗与单纯手术或单纯放疗相比，以及单纯手术与单纯放疗相比，均无显著差异。手术联合放疗与单纯放疗相比的挽救优势比为3.5，接近但未达到统计学显著性。本研究表明，使用手术、放疗或手术联合放疗挽救局部嗅神经母细胞瘤复发有合理的成功率。
