Oesman Chenur, Mooij Jan Jakob A
Skull Base. 2011 Sep;21(5):313-22. doi: 10.1055/s-0031-1284213.
We conducted a study to evaluate the follow-up characteristics of patients with trigeminal neuralgia (TN) and to evaluate the factors affecting long-term outcome of microvascular decompression (MVD) in TN. Between 1983 and 2003, 156 patients with TN treated with MVD by 4 neurosurgeons at University Medical Centre Groningen/the Netherlands were evaluated. Baseline data from operative outcome were evaluated using univariate and multivariate analysis. The group consisted of 156 patients with TN: 90 females and 66 males with a median follow-up period of 9.7 years. The average age of initial symptoms was 51 years. The average duration of symptoms was 58 months. Postoperative 22 patients had a facial hyperpathia or hyperesthesia. Postoperatively, 137 patients had immediate relief. Postoperatively 1 year, 140 patients still had a good outcome of the operation. Twenty-seven patients with good immediate postoperative results had recurrent pain. From the group of patients with typical TN, 82% had good long-term results after operation. Patients with typical TN and immediate postoperative remission, in univariate analysis, had significantly more often an excellent/good postoperative outcome. Immediate postoperative remission is an independent predictive factor for a good long-term outcome. The long-term results of MVD in majority of patients were good with no mortalities and no major morbidities. Patients with typical TN had better long-term outcomes and less recurrence.
我们开展了一项研究,以评估三叉神经痛(TN)患者的随访特征,并评估影响TN微血管减压术(MVD)长期疗效的因素。1983年至2003年期间,对荷兰格罗宁根大学医学中心的4位神经外科医生治疗的156例TN患者进行了评估。采用单因素和多因素分析对手术结果的基线数据进行评估。该组包括156例TN患者:90例女性和66例男性,中位随访期为9.7年。初始症状的平均年龄为51岁。症状的平均持续时间为58个月。术后22例患者出现面部感觉异常或感觉过敏。术后,137例患者立即缓解。术后1年,140例患者手术效果仍良好。27例术后即刻效果良好的患者出现复发性疼痛。在典型TN患者组中,82%术后长期效果良好。在单因素分析中,典型TN且术后即刻缓解的患者术后优秀/良好结局的比例显著更高。术后即刻缓解是长期良好结局的独立预测因素。MVD对大多数患者的长期效果良好,无死亡病例和严重并发症。典型TN患者的长期结局更好,复发更少。