意大利急性冠状动脉综合征网络（IN-ACS 结局研究）中急性冠状动脉综合征的临床流行病学、管理及结局

Clinical epidemiology, management and outcome of acute coronary syndromes in the Italian network on acute coronary syndromes (IN-ACS Outcome study).

作者信息

Rizzello Vittoria, Lucci Donata, Maggioni Aldo P, Giampaoli Simona, Greco Cesare, Di Pasquale Giuseppe, Pallotti Maria Giovanna, Mureddu Gian Francesco, Di Chiara Antonio, Boccanelli Alessandro

机构信息

San Giovanni-Addolorata Hospital, Department of Cardiology, Rome, Italy.

出版信息

Acute Card Care. 2012 Jun;14(2):71-80. doi: 10.3109/17482941.2012.655296. Epub 2012 Mar 27.

DOI:10.3109/17482941.2012.655296

PMID:22452295

Abstract

BACKGROUND

The Italian network on acute coronary syndromes outcome (IN-ACS Outcome) study is a nationwide observational, multicenter study with the aim to describe clinical epidemiology, management, 30-days and one-year outcomes of ACS in Italy.

METHODS

All consecutive patients admitted for ACS to 38 hospitals, between December 2005 and February 2007, were enrolled in the study. Patient in-hospital details and follow-up data at 30-days and one-year were collected using a web-based CRF and stored in a central database.

RESULTS

A total of 6045 patients (age 68 ± 13 years) were enrolled: 2313 patients (38.3%) had ST elevation myocardial infarction (STEMI) and 3732 (61.7%) patients had NSTE-ACS. Primary PCI was performed in 1085 (46.9%) STEMI patients, thrombolysis in 590 (25.5%) patients, whereas 638 (27.6%) patients were not reperfused. Among patients with NSTE-ACS, coronary angiography was performed in 2797 (75%) patients, PCI in 1797 (48.2%) patients and CABG in 213 (5.7%) patients. Thirty-days and one-year mortality rates were 5.8% and 9.8%, in STEMI patients and 3.1% and 8.6%, in NSTE-ACS patients.

CONCLUSIONS

The IN-ACS Outcome study showed that the management of ACS is still suboptimal. Although 30-days mortality is low, the one-year mortality is still substantial.

摘要

背景

意大利急性冠状动脉综合征结局研究网络（IN-ACS Outcome）是一项全国性观察性多中心研究，旨在描述意大利急性冠状动脉综合征（ACS）的临床流行病学、治疗情况、30天和1年结局。

方法

纳入2005年12月至2007年2月期间38家医院收治的所有连续ACS患者。使用基于网络的病例报告表收集患者住院详细信息以及30天和1年的随访数据，并存储在中央数据库中。

结果

共纳入6045例患者（年龄68±13岁）：2313例患者（38.3%）为ST段抬高型心肌梗死（STEMI），3732例患者（61.7%）为非ST段抬高型急性冠状动脉综合征（NSTE-ACS）。1085例（46.9%）STEMI患者接受了直接经皮冠状动脉介入治疗（PCI），590例（25.5%）患者接受了溶栓治疗，而638例（27.6%）患者未进行再灌注治疗。在NSTE-ACS患者中，2797例（75%）患者接受了冠状动脉造影，1797例（48.2%）患者接受了PCI，213例（5.7%）患者接受了冠状动脉旁路移植术（CABG）。STEMI患者30天和1年死亡率分别为5.8%和9.8%，NSTE-ACS患者分别为3.1%和8.6%。