Rizzello Vittoria, Lucci Donata, Maggioni Aldo P, Giampaoli Simona, Greco Cesare, Di Pasquale Giuseppe, Pallotti Maria Giovanna, Mureddu Gian Francesco, Di Chiara Antonio, Boccanelli Alessandro
San Giovanni-Addolorata Hospital, Department of Cardiology, Rome, Italy.
Acute Card Care. 2012 Jun;14(2):71-80. doi: 10.3109/17482941.2012.655296. Epub 2012 Mar 27.
The Italian network on acute coronary syndromes outcome (IN-ACS Outcome) study is a nationwide observational, multicenter study with the aim to describe clinical epidemiology, management, 30-days and one-year outcomes of ACS in Italy.
All consecutive patients admitted for ACS to 38 hospitals, between December 2005 and February 2007, were enrolled in the study. Patient in-hospital details and follow-up data at 30-days and one-year were collected using a web-based CRF and stored in a central database.
A total of 6045 patients (age 68 ± 13 years) were enrolled: 2313 patients (38.3%) had ST elevation myocardial infarction (STEMI) and 3732 (61.7%) patients had NSTE-ACS. Primary PCI was performed in 1085 (46.9%) STEMI patients, thrombolysis in 590 (25.5%) patients, whereas 638 (27.6%) patients were not reperfused. Among patients with NSTE-ACS, coronary angiography was performed in 2797 (75%) patients, PCI in 1797 (48.2%) patients and CABG in 213 (5.7%) patients. Thirty-days and one-year mortality rates were 5.8% and 9.8%, in STEMI patients and 3.1% and 8.6%, in NSTE-ACS patients.
The IN-ACS Outcome study showed that the management of ACS is still suboptimal. Although 30-days mortality is low, the one-year mortality is still substantial.
意大利急性冠状动脉综合征结局研究网络（IN-ACS Outcome）是一项全国性观察性多中心研究，旨在描述意大利急性冠状动脉综合征（ACS）的临床流行病学、治疗情况、30天和1年结局。
纳入2005年12月至2007年2月期间38家医院收治的所有连续ACS患者。使用基于网络的病例报告表收集患者住院详细信息以及30天和1年的随访数据，并存储在中央数据库中。
共纳入6045例患者（年龄68±13岁）：2313例患者（38.3%）为ST段抬高型心肌梗死（STEMI），3732例患者（61.7%）为非ST段抬高型急性冠状动脉综合征（NSTE-ACS）。1085例（46.9%）STEMI患者接受了直接经皮冠状动脉介入治疗（PCI），590例（25.5%）患者接受了溶栓治疗，而638例（27.6%）患者未进行再灌注治疗。在NSTE-ACS患者中，2797例（75%）患者接受了冠状动脉造影，1797例（48.2%）患者接受了PCI，213例（5.7%）患者接受了冠状动脉旁路移植术（CABG）。STEMI患者30天和1年死亡率分别为5.8%和9.8%，NSTE-ACS患者分别为3.1%和8.6%。
IN-ACS Outcome研究表明，ACS的治疗仍未达到最佳水平。尽管30天死亡率较低，但1年死亡率仍然较高。
