Department of Obstetrics and Gynecology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Gynecol Endocrinol. 2012 Aug;28(8):590-3. doi: 10.3109/09513590.2011.650754. Epub 2012 Mar 28.
To evaluate the prevalence of thrombophilic disorders in polycystic ovarian syndrome (PCOS) women with history of recurrent pregnancy loss (RPL).
This study was carried out in 184 women with history of RPL, of which 92 of them were diagnosed with PCOS and 92 patients were without known PCOS. The prevalence of thrombophilic disorders was compared between the two mentioned groups.
According to the findings, 70.7% of PCOS women with history of RPL had thrombophilic disorders. The prevalence of protein C deficiency was significantly higher in PCOS group compared to the non-PCOS group (21.7% vs. 10.9%, p = 0.04). There was a trend toward higher prevalence of protein S deficiency in PCOS group compared to the control group, but the difference did not reach statistical significance (23.9% vs. 13%, p = 0.05). The prevalence of other thrombophilic disorders such as antithrombin III deficiency, homocysteine elevation, antiphospholipid antibody and Factor V Leiden was comparable between groups.
The prevalence of thrombophilic disorders was more common in PCOS women than the normal group. The protein C deficiency is associated with PCOS in women with history of RPL. There was a trend toward higher prevalence of protein S deficiency in PCOS women, which needs further study.
评估有复发性妊娠丢失（RPL）史的多囊卵巢综合征（PCOS）女性中血栓形成倾向障碍的发生率。
本研究共纳入 184 例有 RPL 史的女性，其中 92 例被诊断为 PCOS，92 例为非 PCOS。比较了这两组患者中血栓形成倾向障碍的发生率。
根据研究结果，70.7%有 RPL 史的 PCOS 女性患有血栓形成倾向障碍。与非 PCOS 组相比，PCOS 组中蛋白 C 缺乏症的发生率明显更高（21.7% vs. 10.9%，p=0.04）。与对照组相比，PCOS 组中蛋白 S 缺乏症的发生率也呈上升趋势，但差异无统计学意义（23.9% vs. 13%，p=0.05）。其他血栓形成倾向障碍，如抗凝血酶 III 缺乏症、同型半胱氨酸升高、抗磷脂抗体和因子 V Leiden 等在两组之间的发生率相似。
与正常组相比，PCOS 女性血栓形成倾向障碍的发生率更高。有 RPL 史的 PCOS 女性中蛋白 C 缺乏与 PCOS 相关。PCOS 女性中蛋白 S 缺乏症的发生率呈上升趋势，需要进一步研究。
