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双侧去骨瓣减压术治疗非穿透性创伤性脑损伤。

Bilateral hemicraniectomy in non-penetrating traumatic brain injury.

机构信息

Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

出版信息

J Neurotrauma. 2012 Jul 1;29(10):1879-85. doi: 10.1089/neu.2012.2382. Epub 2012 May 14.

Abstract

Traumatic brain injury is a heterogeneous entity that encompasses both surgical and non-surgical conditions. Surgery may be indicated with traumatic lesions such as hemorrhage, fractures, or malignant cerebral edema. However, the neurological exam may be clouded by the effects of medications administered in the field, systemic injuries, and inaccuracies in hyperacute prognostication. Typically, neurological injury is considered irreversible if diffuse loss of grey/white matter differentiation or if brainstem hemorrhage (Duret hemorrhage) exists. We aim to characterize a cohort of patients undergoing bilateral hemicraniectomy for severe traumatic brain injury. A retrospective consecutive cohort of adult patients undergoing craniectomy for trauma was established between the dates of January 2008 and November 2011. The primary outcome of the study was in-hospital mortality. Secondary outcomes were ICU length of stay, surgical complications, and Glasgow Outcome Score at most recent follow-up. During the study period, 210 patients undergoing craniectomy for traumatic mass-occupying lesion (epidural hematoma, subdural hematoma, or parenchymal contusion) were analyzed. Of those, 9 met study criteria. In-hospital mortality was 67% (6 of 9 patients). The average ICU length of stay was 12 days. The GOS score was 3 in surviving patients. Bilateral hemicraniectomy is a heroic intervention for patients with severe TBI, but can be a life-saving procedure.

摘要

创伤性脑损伤是一种异质实体,包括手术和非手术条件。手术可能与创伤性病变有关,如出血、骨折或恶性脑水肿。然而,神经检查可能会受到现场给予的药物、全身损伤和超急性预后不准确的影响。通常,如果存在弥漫性灰质/白质分化丧失或脑干出血(Duret 出血),则认为神经损伤是不可逆的。我们旨在描述一组因严重创伤性脑损伤而行双侧去骨瓣减压术的患者。在 2008 年 1 月至 2011 年 11 月期间,建立了一个回顾性连续队列的成年创伤性开颅术患者。该研究的主要结果是住院死亡率。次要结果是 ICU 住院时间、手术并发症和最近随访时的格拉斯哥预后评分。在研究期间,分析了 210 例因创伤性占位病变(硬膜外血肿、硬膜下血肿或脑实质挫伤)而行开颅术的患者。其中,9 例符合研究标准。住院死亡率为 67%(9 例中的 6 例)。ICU 住院时间平均为 12 天。存活患者的 GOS 评分为 3。双侧去骨瓣减压术是治疗严重 TBI 患者的英勇干预措施,但也可能是一种救命手术。

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