Disease Management Group, Tata Memorial Centre, Mumbai, India.
Leuk Lymphoma. 2012 Nov;53(11):2192-4. doi: 10.3109/10428194.2012.679936. Epub 2012 Apr 30.
Arsenic trioxide, believed to be a carcinogen and a teratogen, has found its niche in the treatment of acute promyelocytic leukemia (APL). APL is a disease affecting young patients. Post-treatment fertility and outcome of pregnancy are always a concern in a disease with high cure rates. We report a case series of six patients who were treated successfully for APL with arsenic trioxide and who parented at least one healthy offspring after completing their treatment.
三氧化二砷,被认为是一种致癌剂和致畸剂,在治疗急性早幼粒细胞白血病(APL)方面找到了自己的位置。APL 是一种影响年轻患者的疾病。在高治愈率的疾病中,治疗后的生育能力和妊娠结局一直是人们关注的问题。我们报告了一系列成功接受三氧化二砷治疗 APL 的六例患者,他们在完成治疗后至少生育了一个健康的后代。