Takeuchi Yoshinori, Takahashi Masashi, Tsuboi Masaya, Fujino Yasuhito, Uchida Kazuyuki, Ohno Koichi, Nakayama Hiroyuki, Tsujimoto Hajime
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Tokyo 113-8657, Japan.
J Vet Med Sci. 2012 Aug;74(8):1057-62. doi: 10.1292/jvms.12-0064. Epub 2012 Mar 28.
A Japanese domestic long-hair cat of about 8 years of age was presented with vomiting and hematochezia and was found to have significant hypereosinophilia. Bone marrow aspiration revealed moderate increases of eosinophilic lineages. Histopathological examination revealed mild eosinophilic and epitheliotropic T-lymphocytic infiltrations in the duodenum. Although the cat remained asymptomatic with only prednisolone administration, the cat presented with hematemesis, weight loss, and severe anorexia 512 days after the initial presentation. Subsequently, gastrointestinal perforation developed, and the cat died on Day 536. Histopathological examination of autopsy specimens revealed mixed cellular infiltration including eosinophils and neoplastic lymphocytes in the intestinal lymph nodes, intestine, liver, spleen, and pancreas. Immunohistochemical examination supports a diagnosis of intestinal T-cell lymphoma with severe hypereosinophilic syndrome.
一只约8岁的日本家养长毛猫出现呕吐和便血症状，发现有明显的嗜酸性粒细胞增多。骨髓穿刺显示嗜酸性粒细胞系中度增加。组织病理学检查显示十二指肠有轻度嗜酸性粒细胞和亲上皮性T淋巴细胞浸润。尽管仅给予泼尼松龙治疗后猫仍无症状，但在初次就诊512天后，猫出现呕血、体重减轻和严重厌食。随后发生胃肠道穿孔，猫于第536天死亡。尸检标本的组织病理学检查显示，在肠淋巴结、肠、肝、脾和胰腺中有包括嗜酸性粒细胞和肿瘤性淋巴细胞在内的混合细胞浸润。免疫组织化学检查支持诊断为伴有严重嗜酸性粒细胞增多综合征的肠道T细胞淋巴瘤。
