Experimental Transplantation Surgery, Department of General, Visceral and Vascular Surgery, Jena University Hospital, Erlanger Allee 101, D-07747, Jena, Germany.
Adv Exp Med Biol. 2012;740:979-1000. doi: 10.1007/978-94-007-2888-2_45.
Proteinase activated receptors (PARs), a small subfamily of G protein-coupled receptors with four members, PAR₁, PAR₂, PAR₃ and PAR₄, are expressed in various tumours from epithelial origin and can play an important role in tumour progression and metastasis. Within the complex intracellular PAR signaling networks triggered by PARs, an elevation in intracellular free calcium ion concentrations represents a key second messenger system. In this review, we summarize current information about the mechanisms whereby PARs can signal via intracellular calcium in the setting of cancer and we discuss possibilities for using the PAR-Ca(2+) signaling pathway as a target for the therapy of epithelial cancer.
蛋白酶激活受体（PARs）是 G 蛋白偶联受体家族的一个小亚家族，有四个成员，PAR₁、PAR₂、PAR₃ 和 PAR₄，它们在各种上皮来源的肿瘤中表达，并在肿瘤进展和转移中发挥重要作用。在 PARs 触发的复杂的细胞内 PAR 信号网络中，细胞内游离钙离子浓度的升高代表了一个关键的第二信使系统。在这篇综述中，我们总结了目前关于 PAR 如何在癌症环境中通过细胞内钙离子信号的机制的信息，并讨论了将 PAR-Ca(2+)信号通路作为治疗上皮癌的靶点的可能性。
