Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Neurotherapeutics. 2012 Jul;9(3):635-8. doi: 10.1007/s13311-012-0121-1.
Recent work exploring the use of high-molecular weight alcohols to treat essential tremor (ET) has identified octanoic acid as a potential novel tremor-suppressing agent. We used an established harmaline-based mouse model of ET to compare tremor suppression by 1-octanol and octanoic acid. The dose-related effect on digitized motion power within the tremor bandwidth as a fraction of overall motion power was analyzed. Both 1-octanol and octanoic acid provided significant reductions in harmaline tremor. An 8-carbon alkyl alcohol and carboxylic acid each suppress tremor in a pre-clinical mouse model of ET. Further studies are warranted to determine the safety and efficacy of such agents in humans with ET.
最近的研究探索了使用高分子量醇类来治疗原发性震颤(ET),发现辛酸是一种有潜力的新型震颤抑制剂。我们使用已建立的哈尔明诱导的 ET 小鼠模型,比较了 1-辛醇和辛酸对震颤的抑制作用。分析了数字化运动功率在震颤带宽内相对于总运动功率的分数的剂量相关效应。1-辛醇和辛酸均显著减少了哈尔明诱导的震颤。8 个碳的烷基醇和羧酸都能抑制 ET 临床前小鼠模型中的震颤。有必要进一步研究此类药物在 ET 患者中的安全性和疗效。