Shill H A, Bushara K O, Mari Z, Reich M, Hallett M
Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892-1428, USA.
Neurology. 2004 Jun 22;62(12):2320-2. doi: 10.1212/wnl.62.12.2320.
Twenty-one single oral doses of 1-octanol were given to patients with essential tremor (ET) in an open-label dose-escalation study. The drug was well tolerated up to 64 mg/kg. The main side effect was an unusual taste. No overt intoxication was seen. There was evidence for efficacy, with a significant reduction in tremor amplitude as measured by accelerometry and handwriting that was maximal at 2 hours. Higher doses may produce more sustained benefit.
在一项开放标签剂量递增研究中，对特发性震颤（ET）患者给予21次单剂量口服1-辛醇。该药物在高达64mg/kg的剂量下耐受性良好。主要副作用是味觉异常。未观察到明显的中毒现象。有证据表明该药物具有疗效，通过加速度测量法和笔迹测量发现震颤幅度显著降低，在2小时时达到最大。更高剂量可能会产生更持久的益处。
