在常见可变免疫缺陷中，B细胞对CpG的反应与CXCL16表达水平相关。
B cell responses to CpG correlate with CXCL16 expression levels in common variable immunodeficiency.
作者信息
Lougaris Vassilios, Baronio Manuela, Vitali Massimiliano, Tampella Giacomo, Soresina Annarosa, Badolato Raffaele, Plebani Alessandro
机构信息
Pediatrics Clinic and Institute of Molecular Medicine A. Nocivelli, University of Brescia, piazzale Spedali Civili 1, 25123 Brescia, Italy.
出版信息
ScientificWorldJournal. 2012;2012:960219. doi: 10.1100/2012/960219. Epub 2012 Feb 1.
Broad Toll-like receptor 9 (TLR9) signalling defects after CpG in vitro stimulation have been described in common variable immunodeficiency (CVID). CXCL16, a surface receptor, was recently shown to influence cell responses to CpG. We evaluated the expression and function of CXCL16 on B cells from healthy controls and CVID patients. We report that CXCL16 is normally expressed on B cells throughout peripheral maturation. Decreased B cell expression of CXCL16 was observed in a subgroup of CVID patients that correlated with defective in vitro responses to CpG (such as upregulation of CD69, CD86, AICDA, IL-6, and TLR9). Our data suggest that expression levels of a surface receptor, namely, CXCL16, correlate with B cell responses mediated by TLR9 in common variable immunodeficiency.
在常见变异型免疫缺陷（CVID）中，已经描述了体外CpG刺激后广泛的Toll样受体9（TLR9）信号缺陷。CXCL16是一种表面受体，最近被证明会影响细胞对CpG的反应。我们评估了健康对照和CVID患者B细胞上CXCL16的表达和功能。我们报告，CXCL16在整个外周成熟过程中正常表达于B细胞上。在一部分CVID患者中观察到CXCL16的B细胞表达降低，这与体外对CpG的反应缺陷相关（如CD69、CD86、AICDA、IL-6和TLR9的上调）。我们的数据表明，一种表面受体即CXCL16的表达水平与常见变异型免疫缺陷中由TLR9介导的B细胞反应相关。
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