吲哚拉明对周围血流的影响。
The effect of indoramin on peripheral blood flow.
机构信息
Department of Clinical Pharmacology, St. Bartholomew's Hospital, London.
出版信息
Br J Clin Pharmacol. 1974 Feb;1(1):13-7. doi: 10.1111/j.1365-2125.1974.tb00200.x.
Abstract
1 The effect of indoramin, a new hypotensive agent, on peripheral blood flows of six normal subjects was determined and compared to placebo in a double-blind, randomized study. 2 Indoramin (0.25 mg/kg), administered intravenously, resulted in an increased forearm muscle volume as measured by strain gauge plethysmography and an increase in the skin temperature of the hand but not to the skin of the chest. 3 It is concluded that these effects are the result of α-adrenoceptor blockade.
摘要
在一项随机双盲研究中，我们测定了新型降压药吲达帕胺对 6 名正常受试者外周血流的影响，并与安慰剂进行了比较。
静脉内给予吲达帕胺（0.25mg/kg），结果用应变计体积描记法测量前臂肌肉容积增加，手部皮肤温度升高，但胸部皮肤温度不变。
结论：这些作用是α-肾上腺素能受体阻断的结果。
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本文引用的文献
1
BLOOD FLOW IN THE HAND AND FOREARM AFTER PARAVERTEBRAL BLOCK OF THE SYMPATHETIC GANGLIA. EVIDENCE AGAINST SYMPATHETIC VASODILATOR NERVES IN THE EXTREMITIES OF MAN.交感神经节椎旁阻滞术后手部和前臂的血流。对人体四肢存在交感舒血管神经的质疑。
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Cutaneous vasomotor control in the human head, neck and upper chest.人体头部、颈部和上胸部的皮肤血管舒缩控制
J Physiol. 1962 May;161(2):298-312. doi: 10.1113/jphysiol.1962.sp006887.
3
Are there sympathetic vasodilator nerves to the vessels of the hands.是否存在支配手部血管的交感舒血管神经？
J Physiol. 1956 Mar 28;131(3):647-56. doi: 10.1113/jphysiol.1956.sp005489.
4
The measurement of volume changes in human limbs.人体四肢体积变化的测量。
J Physiol. 1953 Jul;121(1):1-27. doi: 10.1113/jphysiol.1953.sp004926.
5
Comparison of propranolol and I.C.I. 50,172 on isoprenaline-induced increase in skin temperature in man.普萘洛尔与ICI 50,172对异丙肾上腺素引起的人体皮肤温度升高的比较。
Br J Pharmacol. 1969 May;36(1):177P-178P.
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The regional circulation.局部循环。
Annu Rev Physiol. 1971;33:445-78. doi: 10.1146/annurev.ph.33.030171.002305.
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Proceedings: Initial clinical experience with indoramin, a new antihypertensive agent.论文集：新型抗高血压药物吲哚拉明的初步临床经验。
Br J Pharmacol. 1972 Feb;44(2):379P-380P.
8
Quantitative analysis on isolated organs of the autonomic blocking properties of indoramin hydrochloride (Wy 21901).盐酸吲哚拉明（Wy 21901）自主神经阻滞特性的离体器官定量分析。
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10
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Cardiovasc Res. 1972 May;6(3):226-34. doi: 10.1093/cvr/6.3.226.
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