α-肾上腺素能受体阻断药吲哚拉明的抗心律失常特性。
Anti-arrhythmic properties of the alpha-adrenoceptor blocking drug indoramin.
作者信息
James M A, Jones J V
机构信息
Department of Cardiology, Bristol Royal Infirmary.
出版信息
Br J Clin Pharmacol. 1991 Sep;32(3):375-8. doi: 10.1111/j.1365-2125.1991.tb03915.x.
Abstract
- The anti-arrhythmic properties of the alpha-adrenoceptor blocking drug indoramin were compared with the effect of disopyramide and placebo in a randomised, single-blind, cross-over study. Two doses of indoramin were tested, 25 mg and 50 mg and the dose of disopyramide was 150 mg. All treatments were administered three times daily. 2. Forty patients with benign ventricular arrhythmia were studied. 3. Assessment was by 24 h ambulatory electrocardiography at entry and at the end of each 2 week treatment period. 4. Indoramin was found to have a significant anti-arrhythmic effect compared with placebo, but only at the higher dose tested. 5. The anti-arrhythmic effect was less than that achieved with disopyramide. 6. The mechanism for this anti-arrhythmic effect is unknown but these results suggest that alpha-adrenoceptor blockade may merit further attention as an anti-arrhythmic treatment.
摘要
- 在一项随机、单盲、交叉研究中，将α-肾上腺素能受体阻断药物吲哚拉明的抗心律失常特性与丙吡胺和安慰剂的效果进行了比较。测试了两种剂量的吲哚拉明，分别为25毫克和50毫克，丙吡胺的剂量为150毫克。所有治疗均每日给药三次。2. 对40例良性室性心律失常患者进行了研究。3. 在入组时以及每个2周治疗期结束时，通过24小时动态心电图进行评估。4. 发现与安慰剂相比，吲哚拉明具有显著的抗心律失常作用，但仅在测试的较高剂量时。5. 其抗心律失常作用小于丙吡胺所达到的效果。6. 这种抗心律失常作用的机制尚不清楚，但这些结果表明，α-肾上腺素能受体阻断作为一种抗心律失常治疗可能值得进一步关注。
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