去甲异喹胍与人酚噻嗪的相互作用。
Interaction between debrisoquine and phenylephrine in man.
机构信息
Department of Pharmacology and Therapeutics, London Hospital Medical College, Turner Street, London.
出版信息
Br J Clin Pharmacol. 1974 Feb;1(1):51-7. doi: 10.1111/j.1365-2125.1974.tb00206.x.
Abstract
1 The interaction between phenylephrine and debrisoquine was studied using normal and hypertensive human volunteers, measuring blood pressure, pulse rate and pupil diameter. Single doses of phenylephrine were given before, during and after a short course of debrisoquine treatment. 2 The circulatory effects of phenylephrine are potentiated by debrisoquine; in a few subjects this potentiation was marked and a potential hazard. 3 Limited deductions could be made about the effects of debrisoquine on baroceptor responses and adrenergic mechanisms.
摘要
- 本研究使用正常人和高血压志愿者，通过测量血压、脉搏和瞳孔直径，考察了去甲肾上腺素和地昔帕明之间的相互作用。志愿者在接受短期地昔帕明治疗前后，单次给予去甲肾上腺素。 2. 地昔帕明增强了去甲肾上腺素的循环作用；在少数对象中，这种增强作用非常显著，存在潜在危险。 3. 地昔帕明对压力感受器反应和肾上腺素能机制的影响可作有限的推断。
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Interaction between debrisoquine and phenylephrine in man.去甲异喹胍与人酚噻嗪的相互作用。
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本文引用的文献
1
TREATMENT OF HYPERTENSION WITH DEBRISOQUIN SULFATE (DECLINAX).
Curr Ther Res Clin Exp. 1965 May;7:289-96.
2
A comparison of some atropine-like drugs in man, with particular reference to their end-organ specificity.人体中某些类阿托品药物的比较，特别涉及其终末器官特异性。
Br J Pharmacol Chemother. 1958 Jun;13(2):184-92. doi: 10.1111/j.1476-5381.1958.tb00215.x.
3
The influence of debrisoquin on the accumulation and metabolism of biogenic amines by the human platelet, in vivo and in vitro.体内及体外条件下，异喹胍对人血小板生物胺积累及代谢的影响。
Clin Pharmacol Ther. 1969 Mar-Apr;10(2):229-38. doi: 10.1002/cpt1969102229.
4
Monoamine oxidase inhibitors.单胺氧化酶抑制剂
Pharmacol Rev. 1966 Mar;18(1):121-9.
5
Interactions between catecholamines and tricyclic and monoamine oxidase inhibitor antidepressive agents in man.人体内儿茶酚胺与三环类及单胺氧化酶抑制剂抗抑郁药之间的相互作用。
Br J Pharmacol. 1971 Oct;43(2):472P-473P.
6
The effects of debrisoquin and bretylium on adrenergic nerves as revealed by fluorescence histochemistry.
J Pharmacol Exp Ther. 1970 Jul;174(1):99-110.
7
Reflex regulation of arterial pressure during sleep in man. A quantitative method of assessing baroreflex sensitivity.人类睡眠期间动脉血压的反射调节。一种评估压力感受性反射敏感性的定量方法。
Circ Res. 1969 Jan;24(1):109-21. doi: 10.1161/01.res.24.1.109.
8
Diminished baroreflex sensitivity in high blood pressure.高血压患者压力反射敏感性降低。
Circulation. 1969 Jan;39(1):48-54. doi: 10.1161/01.cir.39.1.48.
9
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