不同剂量普萘洛尔对人体氧合血红蛋白亲和力的急性影响。
Acute effects of varying doses of propranolol upon oxygen haemoglobin affinity in man.
机构信息
McMaster University Medical Centre, Hamilton, Ontario, Canada.
出版信息
Br J Clin Pharmacol. 1974 Feb;1(1):67-70. doi: 10.1111/j.1365-2125.1974.tb00208.x.
1 The effect of propranolol 2 h following doses of 10, 30, or 100 mg upon the blood oxygen-haemoglobin dissociation curves has been studied in four normal subjects. 2 The pO(2) at 50% saturation (p50) was not changed significantly under control conditions or after 10 and 100 mg doses. There was a just significant increase of 2 mmHg in the p50 value after the 30 mg dose. 3 There was no significant change in red cell adenosine triphosphate or 2,3-diphosphoglycerate nor in plasma phosphate. 4 There was no correlation between plasma propranolol concentration and changes in blood p50.
在四名正常受试者中，研究了在给药后 10、30 或 100mg 普萘洛尔 2 小时后对血氧-血红蛋白解离曲线的影响。
在对照条件下或在给予 10 和 100mg 剂量后，50%饱和度时的 pO(2)（p50）没有显著改变。在给予 30mg 剂量后，p50 值仅增加 2mmHg。
红细胞三磷酸腺苷或 2,3-二磷酸甘油酸或血浆磷酸盐均无显著变化。
血浆普萘洛尔浓度与血液 p50 变化之间无相关性。
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