The renal excretion of mexiletine (Kö 1173) under controlled conditions of urine pH.
作者信息
Kiddie M A, Kaye C M
出版信息
Br J Clin Pharmacol. 1974 Feb;1(1):86-7. doi: 10.1111/j.1365-2125.1974.tb00214.x.
Abstract
摘要
相似文献
1
The renal excretion of mexiletine (Kö 1173) under controlled conditions of urine pH.在尿液pH值可控条件下美西律（Kö 1173）的肾脏排泄情况。
Br J Clin Pharmacol. 1974 Feb;1(1):86-7. doi: 10.1111/j.1365-2125.1974.tb00214.x.
2
The effect of spontaneous changes in urinary pH on mexiletine plasma concentrations and excretion during chronic administration to healthy volunteers.健康志愿者长期服用美西律期间，尿pH值自发变化对美西律血浆浓度及排泄的影响。
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3
Mexiletine disposition: individual variation in response to urine acidification and alkalinisation.美西律的处置：对尿液酸化和碱化反应的个体差异。
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Influence of debrisoquine hydroxylation phenotype on the pharmacokinetics of mexiletine.异喹胍羟化代谢表型对美西律药代动力学的影响。
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Role of the Rhesus glycoprotein, Rh B glycoprotein, in renal ammonia excretion.恒河猴糖蛋白（Rh B 糖蛋白）在肾脏氨排泄中的作用。
Am J Physiol Renal Physiol. 2010 Nov;299(5):F1065-77. doi: 10.1152/ajprenal.00277.2010. Epub 2010 Aug 18.
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Pharmacokinetics of mexiletine enantiomers in healthy human subjects. A study of the in vivo serum protein binding, salivary excretion and red blood cell distribution of the enantiomers.美西律对映体在健康人体受试者中的药代动力学。对映体的体内血清蛋白结合、唾液排泄及红细胞分布研究。
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Baseline pharmacology, electrophysiology and pharmacokinetics of mexiletine.美西律的基线药理学、电生理学和药代动力学
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Stereoselective disposition of mexiletine in man.美西律在人体中的立体选择性分布。
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Effect of intercalated cell-specific Rh C glycoprotein deletion on basal and metabolic acidosis-stimulated renal ammonia excretion.细胞间腔特异性 Rh C 糖蛋白缺失对基础和代谢性酸中毒刺激的肾脏氨排泄的影响。
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10
The influence of urinary pH on the elimination of mexiletine.尿液 pH 值对美西律消除的影响。
Br J Clin Pharmacol. 1974 Jun;1(3):229-32. doi: 10.1111/j.1365-2125.1974.tb00241.x.
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Is there an ideal antiarrhythmic drug? A review--with particular reference to class I antiarrhythmic agents.是否存在理想的抗心律失常药物？一篇综述——特别提及I类抗心律失常药物。
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本文引用的文献
1
RHYTHMIC URINARY EXCRETION OF AMPHETAMINE IN MAN.
Nature. 1964 Dec 19;204:1203-4. doi: 10.1038/2041203a0.
2
Preliminary studies on the pharmacology of an antidysrhythmic, Kö 1173, in man.抗心律失常药物Kö 1173在人体中的药理学初步研究。
Br J Pharmacol. 1973 Mar;47(3):674P-675P.
3
Urinary excretion kinetics of amphetamine in man.
J Pharm Pharmacol. 1965 Oct;17(10):628-39. doi: 10.1111/j.2042-7158.1965.tb07575.x.
4
Spectrophotofluorometric and gas-liquid chromatographic methods for the estimation of mexiletine (Kö 1173) in plasma and urine.
J Pharm Pharmacol. 1973 Jul;25(7):550-3. doi: 10.1111/j.2042-7158.1973.tb09155.x.
5
Mexiletine (Kö 1173) in the management of ventricular dysrhythmias.美西律（Kö 1173）用于室性心律失常的治疗。
Lancet. 1973 Aug 25;2(7826):404-7. doi: 10.1016/s0140-6736(73)92271-x.
6
Treatment of ventricular arrhythmias with mexiletine (Kö 1173).美西律（Kö 1173）治疗室性心律失常
Lancet. 1973 Aug 25;2(7826):399-404. doi: 10.1016/s0140-6736(73)92270-8.
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