盐酸土霉素二水合物片的生物利用度和体外溶出度。
Biological availability and in vitro dissolution of oxytetracycline dihydrate tablets.
机构信息
Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool.
出版信息
Br J Clin Pharmacol. 1974 Oct;1(5):405-8. doi: 10.1111/j.1365-2125.1974.tb00277.x.
1 The concentration of oxytetracycline in plasma was studied by microbiological assay after oral administration of four different preparations of oxytetracycline dihydrate tablets. 2 There were statistically significant differences in biological availability between the four preparations, as assessed by the peak plasma level, the area under the plasma concentration-time curve, or the cumulative fraction of the dose excreted in urine at 405 minutes. In contrast, differences between the subjects were not statistically significant. 3 The differences in biological availability were not predictably related to the in vitro dissolution of the tablets.
给四种不同的氧四环素二水合物片剂口服制剂后，通过微生物检测法研究了血浆中氧四环素的浓度。
从四个方面评估，即：血浆浓度-时间曲线下的面积、在 405 分钟时尿液中排泄的剂量的累积分数、峰值血浆水平，这四种制剂的生物利用度存在统计学差异。相比之下，受试者之间的差异没有统计学意义。
生物利用度的差异与片剂的体外溶解没有可预测的关系。
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